Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis.
Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis.
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急性自限性暴发性肝炎患者血清可溶性Fas配体检测的临床意义
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
H. Kawasaki
中科院分区：
文献类型：
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作者：
G. Shiota;K. Oyama;N. Noguchi;Y. Takano;S. Kitaoka;H. Kawasaki
Fas 配体 (FasL) 是肿瘤坏死因子家族的成员，可诱导表达 Fas 的细胞凋亡。基质金属蛋白酶样酶会裂解膜结合的 FasL，产生可溶性 FasL (sFasL)。由于据报道 FasL 在肝炎的发展中发挥着关键作用，我们评估了血清 sFasL 在急性肝损伤（包括急性自限性和暴发性肝炎）中的临床意义。采用酶联免疫吸附法（ELISA）检测19例患者的血清sFasL，其中12例为急性自限性肝炎，7例为暴发性肝炎。临床数据包括年龄、性别、肝功能检查、肝细胞生长因子（HGF）、预后和sFasL等18项指标。暴发性肝炎血清sFasL为0.06+/-0.01 ng/ml，与急性自限性肝炎相同，血清sFasL与AST、ALT呈正相关（p<0.0001和p<0.0001）。与患者预后相关的因素依次为HGF、白蛋白、凝血酶原时间、血小板计数、胆碱酯酶和白细胞计数。血清 sFasL 可作为急性自限性和暴发性肝炎肝损伤的指标。
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas-expressing cells. A matrix metalloproteinase-like enzyme cleaves the membrane-bound FasL to produce the soluble FasL (sFasL). Since FasL has been reported to play a pivotal role in the development of hepatitis, we evaluated clinical significance of serum sFasL in acute liver injury including acute self-limited and fulminant hepatitis. Serum sFasL in 19 patients including 12 with acute self-limited hepatitis and 7 with fulminant hepatitis was measured by an enzyme-linked immunosorbent assay (ELISA). The clinical data consisted of 18 indices including age, sex, liver function tests, hepatocyte growth factor (HGF), outcome and sFasL. Serum sFasL in fulminant hepatitis is 0.06+/-0.01 ng/ml, being identical to that in acute self-limited hepatitis, Serum sFasL is positively correlated with AST and ALT (p<0.0001 and p<0.0001). The factors associated with outcome of the patients were HGF, albumin, prothrombin time, platelet count, cholinesterase and leukocyte count in this order. Serum sFasL serves as an indicator of liver injury in acute self-limited and fulminant hepatitis.