The Evolution of Enzyme Catalytic Efficiency and Adaptive Inference from Steady-State Kinetic Data
The Evolution of Enzyme Catalytic Efficiency and Adaptive Inference from Steady-State Kinetic Data
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酶催化效率的演变和稳态动力学数据的自适应推理
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. K. Koehn
中科院分区：
文献类型：
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作者：
J. G. Hall;R. K. Koehn
在过去的二十年里，分子水平上的适应研究已成为进化生物学中快速发展的一部分。这种兴趣的部分推动力来自于对植物和动物物种内部和之间同源蛋白质（尤其是酶）的结构多样性的存在和模式进行的解释很大程度上不令人信服的尝试（Lewontin，1974；Nei，1975；Wilson 等，1977；Ayala 等，1976）。额外的动机来自比较生理学以及了解生理适应不同环境的分子基础的需要。这两个兴趣融合在对种间和种内酶变体的功能和进化以及观察到的结构和功能变异在适应中可能发挥的作用的研究中。
In the last two decades the study of adaptation at the molecular level has become a rapidly growing part of evolutionary biology. Some of the impetus for this interest has come from the largely unconvincing attempts to explain the existence and patterns of structural diversity of homologous proteins, especially enzymes, within and among plant and animal species (Lewontin, 1974; Nei, 1975; Wilson et al., 1977; Ayala et al., 1976). Additional motivation has come from comparative physiology and the need to understand the molecular basis of physiological adaptation to different environments. These two interests have merged in the study of the function and evolution of both interspecific and intraspecific enzyme variants and the possible roles the observed structural and functional variation might play in adaptation.
DOI：
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发表时间：
1980
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Andersson,L;Wolfenden,R
通讯作者：
Wolfenden,R