Effects of Obesity and Hypertension on Pulse Wave Velocity in Children
Effects of Obesity and Hypertension on Pulse Wave Velocity in Children
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DOI：
10.1111/jch.12892
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发表时间：
2017-03-01
影响因子：
2.8
通讯作者：
Dharnidharka, Vikas R.
中科院分区：
文献类型：
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作者：
Kulsum-Mecci, Nazia;Goss, Charles;Dharnidharka, Vikas R.
脉搏波速度（PWV）是动脉僵硬度的生物标志物。关于肥胖对儿童PWV的影响，先前研究的结果相互矛盾。作者测量了159名4至18岁儿童的颈动脉-股动脉PWV，其中95名健康儿童，25名肥胖儿童，15名高血压（HTN）儿童，24名肥胖和高血压儿童。平均PWV随年龄增加而增加，但在种族或性别之间没有差异。在对10岁及以上儿童（n=102）的校正分析中，高血压（PWV +/-标准差，4.9 +/- 0.7 m/s）、肥胖（5.0 +/- 0.9 m/s）和肥胖高血压（5.2 +/- 0.6 m/s）儿童的PWV显著高于健康儿童（4.3 +/- 0.7 m/s）（每组，P
Pulse wave velocity (PWV) is a biomarker of arterial stiffness. Findings from prior studies are conflicting regarding the impact of obesity on PWV in children. The authors measured carotid-femoral PWV in 159 children aged 4 to 18 years, of whom 95 were healthy, 25 were obese, 15 had hypertension (HTN), and 24 were both obese and hypertensive. Mean PWV increased with age but did not differ by race or sex. In adjusted analyses in children 10 years and older (n=102), PWV was significantly higher in children with hypertension (PWV +/- standard deviation, 4.9 +/- 0.7 m/s), obesity (5.0 +/- 0.9 m/s), and combined obesity-hypertension (5.2 +/- 0.6 m/s) vs healthy children (4.3 +/- 0.7 m/s) (each group, P