Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naive first-episode major depressive disorder
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naive first-episode major depressive disorder
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DOI：
10.1186/s12888-020-02738-2
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发表时间：
2020-06-24
期刊：
影响因子：
4.4
通讯作者：
Islam, Md. Saiful
中科院分区：
文献类型：
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作者：
Islam, Md. Rabiul;Ali, Samia;Islam, Md. Saiful
背景生物标志物的改变被认为是了解重度抑郁症（MDD）的病理生理学和治疗的有效工具。许多研究暗示了许多抑郁症的标志物，但其中没有一项充分发现了这些标志物与抑郁症之间的关联。本研究调查了重度抑郁症患者血清中氨基酸和非酶抗氧化剂的水平，并解释了它们与抑郁症的关联。方法本研究检查了 247 名 MDD 患者和 248 名年龄和性别相匹配的健康对照 (HC)。所有参与者均使用汉密尔顿抑郁评定量表（Ham-D）来衡量抑郁的严重程度。使用 HPLC 系统对血清氨基酸、维生素 A 和 E 进行定量，而维生素 C 水平则通过紫外分光光度计测量。所有统计分析均采用SPSS统计软件（23.0版）进行。应用独立样本 t 检验、Mann-Whitney U 检验和 Fisher 精确检验来检测组间差异，其中对 p 值进行 Bonferroni 校正。结果观察到，四种氨基酸（蛋氨酸、苯丙氨酸、色氨酸和酪氨酸）以及三种非酶抗氧化剂（维生素 A、E 和 C）的血清水平在 MDD 患者与 HC 患者相比（Cohen's d (d)：分别为-0.45、-0.50、-0.68、-0.21、-0.27、-0.65 和-0.24）。此外，病例的 Ham-D 评分与血清蛋氨酸（r=-0.155，p=0.015）和酪氨酸（r=-0.172，p=0.007）水平呈负相关。 结论本研究表明，血清蛋氨酸、苯丙氨酸、色氨酸、酪氨酸和非酶抗氧化剂降低与抑郁症相关。 MDD 患者这些参数的降低可能是重度抑郁症的结果，而不是原因。
BackgroundThe alterations of biological markers are thought to be effective tools to understand the pathophysiology and management of major depressive disorder (MDD). A lot of researches has implied many markers for depression, but any of them fully discovered the association between the markers and depression. The present study investigated the serum levels of amino acids and non-enzymatic antioxidants in major depression, and also explained their association with depression.MethodsThis study examined 247 MDD patients and 248 healthy controls (HCs) matched by age and sex. The Hamilton Depression Rating Scale (Ham-D) was used to all the participants to measure the severity of depression. Quantification of serum amino acids, vitamin A and E were carried out using the HPLC system whereas vitamin C levels were measured by UV-spectrophotometer. All the statistical analysis was performed by SPSS statistical software (version 23.0). The independent sample t-test, the Mann-Whitney U test, and the Fisher's exact test were applied to detect the group differences where a Bonferroni correction applied to the p value.ResultsIt was observed that serum levels of four amino acids (methionine, phenylalanine, tryptophan, and tyrosine) along with three non-enzymatic antioxidants (vitamin A, E, and C) were significantly dropped in MDD patients compared to HCs (Cohen's d (d): -0.45, -0.50, -0.68, -0.21, -0.27, -0.65, and-0.24, respectively). Furthermore, Ham-D scores of cases were negatively correlated with serum levels of methionine (r=-0.155, p=0.015) and tyrosine (r=-0.172, p=0.007).ConclusionThe present study suggests that lowered serum methionine, phenylalanine, tryptophan, tyrosine, and non-enzymatic antioxidants are associated with depression. The reduction of these parameters in MDD patients may be the consequence, and not the cause, of major depression.