Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.
Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.
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通过基于细胞的 ELISA 检测川崎病的抗内皮细胞抗体。
DOI：
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发表时间：
1991
影响因子：
5.2
通讯作者：
M. Dillon
中科院分区：
文献类型：
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作者：
E. Tizard;E. Baguley;G. Hughes;M. Dillon
川崎病是一种儿童时期的急性血管疾病，发病率和死亡率都很高。应用细胞酶联免疫吸附试验(EL ISA)检测川崎病患儿血清中抗内皮细胞抗体。32例川崎病患者中21例IgM抗体滴度升高，4例Ig G抗内皮细胞抗体滴度升高。IgM抗内皮细胞抗体滴度与正常对照组和发热对照组比较，差异有统计学意义。在连续研究的患者中，抗体滴度与疾病活动性平行。细胞因子刺激后，抗内皮细胞抗体结合率无明显增加。这些发现可能对进一步研究人类这种和其他形式的脉管炎所涉及的机制有重要意义。
Kawasaki disease is an acute vasculitic illness of childhood associated with significant morbidity and mortality. A cellular based enzyme linked immunosorbent assay (ELISA) was used to demonstrate the presence of antiendothelial cell antibodies in sera from children with Kawasaki disease. Twenty one of 32 patients with Kawasaki disease had raised IgM antibody titres and four had raised IgG antiendothelial antibody titres. There was a significant difference in the IgM antiendothelial cell antibody titres when comparing the patients with normals and febrile controls. The antibody titre paralleled the disease activity in patients studied serially. There was no relative increase in binding of antiendothelial cell antibodies after cytokine stimulation. These findings may be of importance in further research into the understanding of mechanisms involved in this and other forms of vasculitis in man.
影响因子：
158.5
作者：
NEWBURGER, JW;TAKAHASHI, M;MELISH, ME
通讯作者：
MELISH, ME