THE T-HELPER CELL RESPONSE IN LYME ARTHRITIS - DIFFERENTIAL RECOGNITION OF BORRELIA-BURGDORFERI OUTER SURFACE PROTEIN-A IN PATIENTS WITH TREATMENT-RESISTANT OR TREATMENT-RESPONSIVE LYME ARTHRITIS
THE T-HELPER CELL RESPONSE IN LYME ARTHRITIS - DIFFERENTIAL RECOGNITION OF BORRELIA-BURGDORFERI OUTER SURFACE PROTEIN-A IN PATIENTS WITH TREATMENT-RESISTANT OR TREATMENT-RESPONSIVE LYME ARTHRITIS
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DOI：
10.1084/jem.180.6.2069
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发表时间：
1994-12-01
影响因子：
15.3
通讯作者：
KAMRADT, T
中科院分区：
文献类型：
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作者：
LENGLJANSSEN, B;STRAUSS, AF;KAMRADT, T
宿主对伯氏疏螺旋体的反应可能在莱姆关节炎的发病机制中起作用。虽然大多数莱姆关节炎患者可以通过抗生素治疗治愈，但约10%的患者在抗生素治疗后仍有持续数月甚至数年的关节炎。在这项研究中，我们检验了这样一个假设：在对治疗有反应和对治疗有抵抗的莱姆关节炎患者中，对伯氏疏螺旋体的一种或多种抗原的T细胞反应是不同的。为此，从4名对治疗有反应的莱姆关节炎患者和5名对治疗有抵抗的关节炎患者的滑液或外周血中获得了313个伯氏疏螺旋体特异性T细胞系。对来自对治疗有反应的莱姆关节炎的87个T细胞系和来自对治疗有抵抗组的112个细胞系进行了检测，以确定它们对5种重组伯氏疏螺旋体蛋白的识别情况：外表面蛋白A（OspA）、B、C、p39和p93。在两组患者中，T细胞系经常识别OspB，只是偶尔识别OspC、p39和p93。相比之下，OspA优先被来自对治疗有抵抗的关节炎患者的T细胞系识别，但很少被来自对治疗有反应的关节炎患者的T细胞系识别（优势比28.4，95%置信区间9.2 - 87.8，p（此处似乎内容不完整）
The host response to Borrelia burgdorferi is likely to play a role in the pathogenesis of Lyme arthritis. Whereas most patients with Lyme arthritis can be cured with antibiotic therapy, similar to 10% of the patients have persistent arthritis for months or even several years after antibiotic treatment. In this study, we tested the hypothesis that the T cell response to one or more antigens of B. burgdorferi is different in patients with treatment-responsive or treatment-resistant Lyme arthritis. For this purpose, 313 B. burgdorferi-specific T cell lines were derived from the synovial fluid or peripheral blood of four patients with treatment-responsive Lyme arthritis and five patients with treatment-resistant arthritis. 87 T cell lines from treatment-responsive Lyme arthritis and 112 lines from the treatment-resistant group were examined for the recognition of five recombinant. B. burgdorferi proteins: outer surface proteins A (OspA), B, C, p39, and p93. In both groups of patients, the T cell lines frequently recognized OspB, and only occasionally recognized OspC, p39, and p93. In contrast, OspA was preferentially recognized by T cell lines from patients with treatment-resistant arthritis, but only rarely recognized by T cell lines from patients with treatment-responsive arthritis (odds ratio 28.4, 95% confidence interval 9.2-87.8, p