HBx-related long non-coding RNA 01152 promotes cell proliferation and survival by IL-23 in hepatocellular carcinoma
HBx-related long non-coding RNA 01152 promotes cell proliferation and survival by IL-23 in hepatocellular carcinoma
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HBx相关长非编码RNA 01152通过IL-23促进肝细胞癌细胞增殖和存活
DOI：
10.1016/j.biopha.2019.108877
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发表时间：
2019-07-01
影响因子：
7.5
通讯作者：
Jia Hao
中科院分区：
文献类型：
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作者：
Chen Tianshi;Pei Jinxian;Jia Hao
越来越多的证据表明，长链非编码RNA（long-noncodingRNA，lncRNA）在B型肝炎病毒（Hepatitisvirus，HBV）感染中起重要作用。然而，lncRNA如何调控肝细胞癌过程的潜在机制在很大程度上仍然未知。在本研究中，我们发现LINC 01152在HBV阳性的肝癌组织和细胞中的表达显著增加，并且在体外被HBx诱导。LINC 01152的过表达可增加肝癌细胞的增殖，促进裸鼠成瘤。机制上，HBx可以增加LINC 01152的转录。升高的LINC 01152与IL-23的启动子区结合，促进其转录活性并上调Stat 3和p-Stat 3的水平。我们的研究结果表明LINC 01152在HBV相关肝细胞癌的发展中起着重要作用，并可能作为肝细胞癌的治疗标志物。
Accumulating evidence suggests that long-noncoding RNA (lncRNA) plays important roles in hepatitis B virus (HBV) infections. However, the mechanism underlying how lncRNA regulate hepatocellular carcinoma process remains largely unknown. In this study we found that the expression of LINC01152 was significantly increased in HBV positive HCC tissues and cells and was induced by HBx in vitro. The overexpression of LINC01152 could increases HCC cell proliferation and promotes tumor formation in nude mice. Mechanistically, HBx could increase the transcription of LINC01152. Elevated LINC01152 binds to the promoter region of IL-23, promoting its transcriptional activity and upregulating the levels of Stat3 and p-Stat3. Our findings suggest that LINC01152 plays an important role in HBV-related hepatocellular carcinoma development and may serve as a therapeutic marker for hepatocellular carcinoma.