Does longevity in beagles injected with bone-seeking radionuclides depend upon radiation dose in the absence of known radiation effects?
Does longevity in beagles injected with bone-seeking radionuclides depend upon radiation dose in the absence of known radiation effects?
复制标题
在没有已知辐射效应的情况下，注射寻骨放射性核素的比格犬的寿命是否取决于辐射剂量？
DOI：
10.1097/00004032-200110000-00011
复制
发表时间：
2001
期刊：
影响因子：
2.2
通讯作者：
Taylor,GN
中科院分区：
文献类型：
--
作者：
Lloyd,RD;Miller,SC;Taylor,GN
对注射 226 Ra、228 Ra、228 Th、241 Am、90 Sr 或单体 239 Pu 的小猎犬组进行的寿命与骨骼辐射剂量函数关系的回归分析表明，在低剂量和剂量率（诱导效应低的剂量率）下，当排除因特定辐射效应而死亡的动物时，死亡年龄似乎与剂量无关，尽管寿命似乎与剂量有关当动物因已确定的辐射效应而死亡且所有剂量都包括在内时。我们初步得出结论，对于接受低剂量和低剂量率的寻骨放射性核素骨骼剂量的哺乳动物来说，在没有辐射诱发的恶性肿瘤或其他辐射效应的情况下，寿命可能并不依赖于骨骼辐射剂量。
Regression analyses of longevity as a function of skeletal radiation dose among groups of beagles injected with 226 Ra, 228 Ra, 228 Th, 241 Am, 90 Sr or monomeric 239 Pu suggested that at low doses and dose-rates (those at which induced effects are low), age at death seems to be independent of dose when animals dying with specific radiation effects were excluded, although longevity does appear to be a function of dose when animals dying with established radiation effects and at all doses were included. We conclude tentatively that, for mammals receiving skeletal dose from bone-seeking radionuclides at low doses and low dose-rates, longevity may not be dependent upon skeletal radiation dose in the absence of radiation-induced malignancies or other radiation effects.