Associations of Systemic Inflammation and Sarcopenia With Survival of Esophageal Carcinoma Patients
Associations of Systemic Inflammation and Sarcopenia With Survival of Esophageal Carcinoma Patients
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DOI：
10.1016/j.athoracsur.2020.03.013
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发表时间：
2020-08-01
影响因子：
4.6
通讯作者：
Seto, Yasuyuki
中科院分区：
文献类型：
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作者：
Sugawara, Kotaro;Yagi, Koichi;Seto, Yasuyuki
背景虽然据报道肌肉减少症和全身炎症都会影响食管癌（EC）患者的长期预后，但其与生存结局的相互关系尚未得到研究。本研究旨在评估肌减少症联合嗜中性粒细胞与淋巴细胞比率（NLR）对食管癌患者食管切除术后生存率的影响。共对378例EC患者进行了回顾性分析。NLR的截止值设定为队列的NLR中位数。根据术前获得的计算机断层扫描计算的骨骼肌指数降低确定肌肉减少症。应用单变量和多变量考克斯风险模型确定不良总生存率和癌症特异性生存率的独立预测因子。肌肉减少症在高NLR组（2.57或更高）中比低NLR组（小于2.57; P = .01）更常见。在高NLR组中，肌肉减少症患者的总体生存率和癌症特异性生存率显著低于无肌肉减少症患者（P
Background. Although both sarcopenia and systemic inflammation reportedly affect long-term outcomes of esophageal carcinoma (EC) patients, their reciprocal associations with survival outcomes have yet to be investigated. This study aimed to evaluate the survival impact of sarcopenia combined with the neutrophil-to-lymphocyte ratio (NLR) in EC patients undergoing esophagectomy.Methods. In total, 378 EC patients were retrospectively reviewed. The cutoff value for NLR was set at the NLR median of the cohort. Sarcopenia was determined based on decreased skeletal muscle index calculated from computed tomography obtained before surgery. Univariate and multivariate Cox hazards models were applied to determine independent predictors of poor overall survival and cancer-specific survival.Results. Sarcopenia was more common in the high-NLR group (2.57 or greater) than in the low-NLR group (less than 2.57; P = .01). In the high-NLR group, patients with sarcopenia had significantly poorer overall and cancer-specific survival than those without sarcopenia (P