Factors affecting successful treatment outcomes in pulmonary tuberculosis: a single-center experience in Turkey, 2005-2011
Factors affecting successful treatment outcomes in pulmonary tuberculosis: a single-center experience in Turkey, 2005-2011
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DOI：
10.3855/jidc.5925
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发表时间：
2015-08-01
影响因子：
1.9
通讯作者：
Tasolar, Fatma Turan
中科院分区：
文献类型：
--
作者：
Sengul, Aysun;Akturk, Ulku Aka;Tasolar, Fatma Turan
简介：我们的目的是描述细菌学确诊的肺结核（PTB）患者的治疗结果，并确定与成功的治疗outcome.Methodology相关的因素：2005年至2011年期间在土耳其科贾埃利结核病防治站接受治疗的涂片和/或培养阳性PTB患者的病历进行了审查。将患者分类为治疗结局成功（治愈或完成治疗）或不良（治疗默认、治疗失败、死亡）。通过单变量和多变量分析评估了人口统计学和临床因素（包括性别、年龄、教育、职业、保险、家庭规模、居住区域、涂片和培养阳性、再治疗、合并症、耐药性和X线片上的空洞）与治疗成功率的关系。在738例经细菌学证实的PTB患者（258例女性，480例男性）中，683例（92.6%）治疗成功。在预后不良的患者中，29例（3.9%）治疗失败，18例（2.4%）死亡，8例（1.1%）治疗失败。年轻、既往未接受过治疗、无合并症、无耐药、高教育水平是成功PTB治疗结局的显著相关因素（p < 0.05）。结论：有耐药、既往治疗史、无合并症的年轻、受过教育的PTB患者治疗结局是成功的。了解影响治疗成功的因素将导致在PTB管理中采取具体措施，这可能有助于减少治疗失败。
Introduction: We aimed to describe the treatment outcomes in patients with bacteriologically confirmed pulmonary tuberculosis (PTB) and identify factors associated with successful treatment outcome.Methodology: The medical charts of patients with smear and/or culture-positive PTB who were treated between 2005 and 2011 at the Kocaeli Tuberculosis Dispensary, Turkey, were reviewed. Patients were categorized as having a successful (cured or with a completed treatment) or poor (treatment default, treatment failure, death) treatment outcome. The association of demographic and clinical factors, including gender, age, education, occupation, insurance, family size, living area, smear and culture positivity, retreatment, comorbidity, drug resistance, and cavity on radiography, with the success of treatment, was evaluated by univariate and multivariate analyses.Results: Of 738 patients (258 females, 480 males) with bacteriologically confirmed PTB, 683 (92.6%) had successful treatment outcomes. Of those with a poor outcome, 29 (3.9%) had treatment default, 18 (2.4%) died, and 8 (1.1%) had treatment failure. Young age, no previous treatment, no comorbidity, no drug resistance, and high education level were factors significantly associated with successful PTB treatment outcome (p < 0.05 for all).Conclusions: Treatment outcome was successful in young and educated PTB patients who had drug resistance, previous treatment history, and no comorbidities. Knowledge of the factors affecting treatment success will lead to the undertaking of specific measures in the management of PTB, which may help to decrease treatment failure.