Zygosity diagnosis in young twins by questionnaire for twins' mothers and twins' self-reports.
Zygosity diagnosis in young twins by questionnaire for twins' mothers and twins' self-reports.
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通过双胞胎母亲问卷和双胞胎自我报告对年轻双胞胎进行接合性诊断。
DOI：
10.1375/13690520460741381
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
A. Asaka
中科院分区：
文献类型：
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作者：
S. Ooki;A. Asaka
本研究采用简单的问卷调查法测定儿童期双胞胎的合子性。研究对象是224对双胞胎及其母亲，其中包括159对同卵双胞胎和65对同性异卵双胞胎，通过包括DNA样本在内的遗传标记进行鉴定。双胞胎母亲回答了19个关于双胞胎相似度的问卷，其中16个是关于双胞胎的身体特征，3个是关于双胞胎相似度和被误解（身份混淆）的频率。双胞胎自己回答了三个只涉及身份混淆的问卷项目。逐步logistic回归分析结果表明：仅使用涉及身份混淆的条目时，母亲问卷的总准确率为91.5%。这一准确率略低于双胞胎在处理几乎相同的身份混淆问题时的自我报告所获得的准确率，双胞胎分别回答的准确率为93.3%。当我们使用全部19个项目时，母亲问卷回答的总准确率提高到95.1%。除了“弄错的频率”，“手指的形状”和“眉毛的形状”这两个身体特征也非常有用。总之，双胞胎的合子性可以通过使用母亲的简单问卷来估计，即使在1岁左右的非常小的双胞胎中也有足够的准确性。
The present study deals with the determination of zygosity in twins of childhood age by simple questionnaire. The subjects were 224 twin pairs and their mothers, consisting of 159 monozygotic and 65 same-sex dizygotic pairs, identified by genetic markers including DNA samples. Mothers of twins responded to 19 questionnaire items dealing with twin similarity in 16 items about physical features and 3 items about the degree of similarity and frequency of being mistaken (confusion of identity) when twins were about 1 year of age. The twins themselves responded to three questionnaire items dealing with only confusion of identity items. The results of stepwise logistic regression analysis were as follows: the total accuracy of the mothers' questionnaire was 91.5% when using only the items dealing with confusion of identity. This accuracy was slightly lower than that obtained by twins' self-reports dealing with nearly the same question items of confusion of identity, answered by both twins separately with 93.3% accuracy. The total accuracy of mothers' questionnaire responses rose to 95.1% when we used all 19 items. In addition to "the frequency of being mistaken", two physical features, namely "shape of fingers" and "shape of eyebrow", were very informative. In conclusion, twin zygosity can be estimated by the use of the mothers' simple questionnaire with sufficient accuracy even in very young twins about 1 year of age.