Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status.
Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status.
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DOI：
10.3390/metabo11040196
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发表时间：
2021-03-26
期刊：
影响因子：
4.1
通讯作者：
Ruiz M
中科院分区：
文献类型：
--
作者：
Tremblay-Gravel M;Fortier A;Baron C;David C;Mehanna P;Ducharme A;Hussin J;Hu Q;Tardif JC;Des Rosiers C;Dupuis J;Ruiz M
脂肪酸(FA)利用缺陷在第一组肺动脉高压(PH)和心力衰竭(HF)中已被很好地描述，但在第二组PH中研究较少。本研究旨在评估心力衰竭所致的肺动脉高压(PH)患者的代谢谱是否与无PH的患者不同。我们对60例射血分数降低的慢性心力衰竭患者和72例健康对照进行了原则证明横断面分析，其中71种能量相关代谢物的循环水平用不同的方法进行了测量。超声心动图将心衰患者分为无肺动脉高压心力衰竭(NOPH-HF)27例，平均肺动脉压(MPAP)21 mm Hg；使用主成分分析(PCA)、协方差分析(ANCOVA)和皮尔逊相关性检验比较组间循环代谢物的分布情况。NPH-HF和PH-HF患者年龄分别为±11岁和68±10岁，基线左心室射血分数分别为27±7%和26±7%。主成分分析分离出的基团，对PH-HF更为明显，其中长链酰基肉碱、乙酰肉碱和单不饱和脂肪酸具有最高的负荷分数。在调整了年龄、性别、肾功能、胰岛素抵抗和N末端脑利钠肽原(NT-proBNP)后，noPH-HF和PH-HF患者的脂相关代谢物水平分别有5/15和8/15与对照组有显著差异。在HF-PH中，循环水平与NT-proBNP相互作用的所有代谢物均与NT-proBNP显著相关，但与HF-noPH无相关性。FA相关代谢物在有或无PH的HF中受到不同程度的影响，并可能传递不良结果，因为它们与PH设置中的NT-proBNP有明显的相关性。
Defects in fatty acid (FA) utilization have been well described in group 1 pulmonary hypertension (PH) and in heart failure (HF), yet poorly studied in group 2 PH. This study was to assess whether the metabolomic profile of patients with pulmonary hypertension (PH) due HF, classified as group 2 PH, differs from those without PH. We conducted a proof-of-principle cross-sectional analysis of 60 patients with chronic HF with reduced ejection fraction and 72 healthy controls in which the circulating level of 71 energy-related metabolites was measured using various methods. Echocardiography was used to classify HF patients as noPH-HF (n = 27; mean pulmonary artery pressure [mPAP] 21 mmHg) and PH-HF (n = 33; mPAP 35 mmHg). The profile of circulating metabolites among groups was compared using principal component analysis (PCA), analysis of covariance (ANCOVA), and Pearson’s correlation tests. Patients with noPH-HF and PH-HF were aged 64 ± 11 and 68 ± 10 years, respectively, with baseline left ventricular ejection fractions of 27 ± 7% and 26 ± 7%. Principal component analysis segregated groups, more markedly for PH-HF, with long-chain acylcarnitines, acetylcarnitine, and monounsaturated FA carrying the highest loading scores. After adjustment for age, sex, kidney function, insulin resistance, and N-terminal pro-brain natriuretic peptide (NT-proBNP), 5/15 and 8/15 lipid-related metabolite levels were significantly different from controls in noPH-HF and PH-HF subjects, respectively. All metabolites for which circulating levels interacted between group and NT-proBNP significantly correlated with NT-proBNP in HF-PH, but none with HF-noPH. FA-related metabolites were differently affected in HF with or without PH, and may convey adverse outcomes given their distinct correlation with NT-proBNP in the setting of PH.
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DOI：
10.1161/circheartfailure.113.000521
发表时间：
2013-09-01
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Djoussé L;Benkeser D;Arnold A;Kizer JR;Zieman SJ;Lemaitre RN;Tracy RP;Gottdiener JS;Mozaffarian D;Siscovick DS;Mukamal KJ;Ix JH
通讯作者：
Ix JH
影响因子：
5.4
作者：
Kalim S;Clish CB;Wenger J;Elmariah S;Yeh RW;Deferio JJ;Pierce K;Deik A;Gerszten RE;Thadhani R;Rhee EP
通讯作者：
Rhee EP
影响因子：
2.6
作者：
Luo N;Craig D;Ilkayeva O;Muehlbauer M;Kraus WE;Newgard CB;Shah SH;Rajagopal S
通讯作者：
Rajagopal S
影响因子：
6.2
作者：
Benza, Raymond L.;Miller, Dave P.;McGoon, Michael D.
通讯作者：
McGoon, Michael D.
DOI：
10.1016/j.echo.2013.01.006
发表时间：
2013-05-01
影响因子：
6.5
作者：
Steckelberg, Rachel C.;Tseng, Andrew S.;Sorajja, Paul
通讯作者：
Sorajja, Paul