Host cell factor CD59 restricts complement lysis of Plasmodium falciparum-infected erythrocytes
Host cell factor CD59 restricts complement lysis of Plasmodium falciparum-infected erythrocytes
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DOI：
10.1002/eji.1830271034
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发表时间：
1997-10-01
影响因子：
5.4
通讯作者：
Lanzer, M
中科院分区：
文献类型：
--
作者：
Wiesner, J;Jomaa, H;Lanzer, M
在这里，我们证明了整个补体级联的组成部分被固定在感染了人类疟疾寄生虫恶性疟原虫的红细胞表面。尽管激活了裂解补体因子，但没有观察到补体介导的寄生红细胞裂解。补体介导的裂解恶性疟原虫感染的红细胞仅在缺乏功能性内源性CD59的情况下发生。这些数据表明，恶性疟原虫感染的红细胞对补体攻击的限制主要是由固有的宿主细胞因子，特别是CD59介导的。
Here we demonstrate that components of the entire complement cascade are fixed on the surface of erythrocytes infected with the human malarial parasite Plasmonium falciparum. Despite the activation of lytic complement factors, no complement-mediated lysis of parasitized erythrocytes was observed. Complement-mediated lysis of P. falciparum-infected erythrocytes occurred only in the absence of functional intrinsic CD59. These data suggest that the restriction of the complement attack of P. falciparum-infected erythrocytes is principally mediated by intrinsic host cell factors, in particular CD59.