THE CANDIDATE PROTOONCOGENE BCL-3 IS RELATED TO GENES IMPLICATED IN CELL LINEAGE DETERMINATION AND CELL-CYCLE CONTROL
THE CANDIDATE PROTOONCOGENE BCL-3 IS RELATED TO GENES IMPLICATED IN CELL LINEAGE DETERMINATION AND CELL-CYCLE CONTROL
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DOI：
10.1016/0092-8674(90)90347-h
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发表时间：
1990-03-23
期刊：
影响因子：
64.5
通讯作者：
MCKEITHAN, TW
中科院分区：
文献类型：
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作者：
OHNO, H;TAKIMOTO, G;MCKEITHAN, TW
在一些慢性淋巴细胞白血病病例中，在易位t(14;19)（q32;q13.1）的断点附近的19号染色体上发现了一个基因bcl-3。人类bcl-3基因的序列分析预测了一个含有7个SW16/cdc10基序串联拷贝的蛋白。这个基序先前在酵母基因中被发现，这些基因调节细胞周期开始时的事件，并在无脊椎动物跨膜蛋白中参与细胞分化途径。在有丝分裂刺激后，正常血细胞中bcl-3的表达显著增加，而易位的白血病细胞的表达明显高于对照。这些结果表明bcl-3是一种原癌基因，当异常表达时可能有助于白血病的发生。
A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SW16/cdc10 motif. This motif was previously identified in yeast genes that regulate events at the start of the cell cycle and in invertebrate transmembrane proteins involved in cell differentiation pathways. Expression of bcl-3 in normal blood cells increases markedly following mitogenic stimulation, and leukemic cells with the translocation show much greater expression than controls. These results suggest that bcl-3 is a proto-oncogene that may contribute to leukemogenesis when abnormally expressed.