Plasma zinc in adults with cystic fibrosis: Correlations with clinical outcomes
Plasma zinc in adults with cystic fibrosis: Correlations with clinical outcomes
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DOI：
10.1016/j.jtemb.2013.10.003
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发表时间：
2014-01-01
影响因子：
3.5
通讯作者：
Mailhot, Genevieve
中科院分区：
文献类型：
--
作者：
Damphousse, Veronic;Mailhot, Marjolaine;Mailhot, Genevieve
背景：锌的状况已被记录在囊性纤维化（CF）的婴儿，儿童和青少年。然而，尽管在CF人群中观察到的预期寿命增加，但令人惊讶的是，缺乏有关CF成人锌状况的数据。本研究的目的是（1）表征锌状态和（2）探讨锌状态和CF成人patients.Methods的临床结果之间的关联：对2009年至2012年期间测量血浆锌的患者进行回顾性图表审查。资料包括人口统计学资料、临床特征、生化指标及共病情况。这些患者表现出良好的营养状态（平均BMI +/- SD：22.7 +/- 3.5）和中度肺部疾病（平均FEV 1 +/- SD：66.3 +/- 22.2）。血浆锌浓度低（
Background: Zinc status has been previously documented in cystic fibrosis (CF) infants, children and adolescents. However, despite the increasing life expectancy observed in CF populations, data regarding zinc status of CF adults are surprisingly lacking. The objectives of this study were to (1) characterize zinc status and (2) explore associations between zinc status and clinical outcomes of CF adult patients.Methods: A retrospective chart review was performed for patients who had their plasma zinc measured between 2009 and 2012. Data included demographics, clinical characteristics, biochemical parameters and co-morbid conditions.Results: A total of 304 CF patients were included in the study. These patients displayed a good nutritional status (mean BMI +/- SD: 22.7 +/- 3.5) and moderate lung disease (mean FEV1 +/- SD: 66.3 +/- 22.2). Low plasma zinc concentration (