MUMPS MENINGOENCEPHALITIS IN CHILDREN
MUMPS MENINGOENCEPHALITIS IN CHILDREN
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DOI：
10.1016/s0022-3476(58)80063-3
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发表时间：
1958-01-01
影响因子：
5.1
通讯作者：
RITTER, BS
中科院分区：
文献类型：
--
作者：
RITTER, BS
本文总结了14岁以下儿童流行性腮腺炎脑膜脑炎的诊治经验。患有这种疾病的病人有30人，平均年龄为7.4岁，男性占总数的19人。病例发生在所有季节，但最流行的是在春季和夏季，有趣的是，脑膜脑炎腮腺炎是最常见的在春季和脑膜脑炎不腮腺炎是最常见的在夏季。后一组有13人，诊断是通过血清学方法进行的。17例腮腺炎患者发病前9天至发病后5天出现涎腺肿胀。30例患者均无舌下、颌下或睾丸受累。腹痛是一个持续和严重的特点，在4例，血清淀粉酶测定后，3例患者被认为是腮腺炎胰腺炎。病情程度被评估为可忽略不计2例，轻度7例，中度17例，重度4例，其中2例出现全身抽搐，治疗主要是对症和支持性治疗，给予2名儿童促肾上腺皮质激素对病程无明显影响。一名6岁男童在康复后2年出现凝视状后遗症。流行性腮腺炎感染的血清学证据需要证明成对血清中抗体滴度的显著差异，一份血清在疾病早期抽取，另一份血清在疾病晚期抽取。然而，这位作者声称，在60%后来被证实为腮腺炎脑膜脑炎的病例中，只要抗S抗体滴度明显高于抗V抗体，就可以根据第一份血清样本的抗体滴度作出腮腺炎感染的推定诊断。Joe.
In this paper the author summarizes his experience of mumps meningo-encephalitis occurring in children under 14 years of age. The number of patients suffering from this illness was 30, the average age being 7.4 years and males constituting 19 of the total. Cases occurred at all seasons but were most prevalent in the spring and summer, and the interesting point emerged that meningo-encephalitis with parotitis was most frequent in the spring and meningo-encephalitis without parotitis was most frequent in the summer. Those in the latter group numbered 13, the diagnosis being made by serological methods. In the 17 associated with parotitis the salivary gland swelling appeared at intervals ranging from 9 days before to 5 days after the meningo-encephalitis. Sublingual, submaxillary or testicular involvement were absent in all 30 patients. Abdominal pain was a persistent and severe feature in 4 instances and after serum amylase determinations 3 patients were considered to have mumps pancreatitis. The degree of illness was assessed as negligible in 2, mild in 7, moderate in 17 and severe in 4, 2 of the last mentioned suffering from generalized convulsions.Treatment was principally symptomatic and supportive, adreno-corticotrophic hormone given to 2 children producing no measurable effect on the course of the disease. Sequelae appeared in the shape of staring spells in a 6-year-old boy 2 years after convalescence. Serological evidence of mumps infection requires the demonstration of significant differences in antibody titres in paired sera, one drawn early and the other late in the disease. However, this author claims that in 60% of cases of subsequently proved mumps meningo-encephalitis a presumptive diagnosis of mumps infection can be made from the antibody titres of the first serum sample, provided the anti-S antibody titre is significantly higher than the anti-V antibody.A. Joe.