Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans
Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans
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DOI：
10.1161/01.hyp.34.2.285
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发表时间：
1999-08-01
期刊：
影响因子：
8.3
通讯作者：
Vaughan, DE
中科院分区：
文献类型：
--
作者：
Brown, NJ;Agirbasli, M;Vaughan, DE
在人肾素-血管紧张素-醛固酮系统激活过程中，血管紧张素转换酶（ACE）抑制显著降低纤溶酶原激活物抑制剂-1 (PAI-1)，而不改变组织纤溶酶原激活物（tPA）。由于ACE抑制剂和血管紧张素II型1 （AT(1)）受体拮抗剂对血管紧张素II形成和缓激肽降解的作用不同，本研究比较了同等降血压剂量的ACE抑制剂和AT(1)拮抗剂对纤溶平衡的影响。在单独低盐摄入（10 mmol Na/d）、低盐摄入+喹诺普利（40 mg PO bid）和低盐摄入+氯沙坦（50 mg PO bid）期间，测定25例血压正常的受试者（白人19例，黑人6例；男性14例，女性11例；平均年龄38.5+/-1.8岁；平均体重指数25.3+/-0.7 kg/m(2)）血浆PAI-1抗原、tPA抗原、血浆肾素活性和醛固酮。与单独使用低盐治疗组（收缩压[BP] 118.8+/-2.2 mmHg）相比，奎普利(106.3+/-2.5 mmHg， P
Angiotensin-converting enzyme (ACE) inhibition significantly decreases plasminogen activator inhibitor-1 (PAI-1) without altering tissue plasminogen activator (tPA) during activation of the renin-angiotensin-aldosterone system in humans. Because ACE inhibitors and angiotensin II type 1 (AT(1)) receptor antagonists differ in their effects on angiotensin II formation and bradykinin degradation, the present study compared the effect of equivalent hypotensive doses of an ACE inhibitor and AT(1) antagonist on fibrinolytic balance. Plasma PAI-1 antigen, tPA antigen, plasma renin activity, and aldosterone were measured in 25 normotensive subjects (19 white, 6 black; 14 men, 11 women; mean age 38.5+/-1.8 years; mean body mass index 25.3+/-0.7 kg/m(2)) during low salt intake alone (10 mmol Na/d), low salt intake + quinapril (40 mg PO bid), and low salt intake + losartan (50 mg PO bid). Compared with low salt alone (systolic blood pressure [BP] 118.8+/-2.2 mmHg), both quinapril (106.3+/-2.5 mmHg, P