Early sexual origins of homeoprotein heterodimerization and evolution of the plant KNOX/BELL family
Early sexual origins of homeoprotein heterodimerization and evolution of the plant KNOX/BELL family
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DOI：
10.1016/j.cell.2008.04.028
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发表时间：
2008-05-30
期刊：
影响因子：
64.5
通讯作者：
Goodenough, Ursula
中科院分区：
文献类型：
--
作者：
Lee, Jae-Hyeok;Lin, Huawen;Goodenough, Ursula
产生多细胞多样性的发育机制被证明在谱系中保存得很好，这引起了人们对它们起源于单细胞祖先的兴趣。我们报道了单细胞绿色土壤藻类衣藻单倍体-二倍体转变的分子调控与陆地植物的分化途径具有共同的祖先。两个同源蛋白Gsp1和Gsm1分别由正配子和负配子贡献，在配子融合时，它们相互作用并从细胞质转移到细胞核，启动合子发育。它们的异位表达激活了营养细胞中的合子发育，在二倍体背景下，产生的合子进行正常的减数分裂。Gsm1/Gsp1双体与调节陆地植物干细胞（分生组织）分化的KNOX/BELL双体具有序列同源性，并在功能上相关。我们提出基于组合同源蛋白的转录控制，真菌/动物辐射的核心特征，可能起源于性背景，并使陆地-植物体计划进化。
Developmental mechanisms that yield multicellular diversity are proving to be well conserved within lineages, generating interest in their origins in unicellular ancestors. We report that molecular regulation of the haploid-diploid transition in Chlamydomonas, a unicellular green soil alga, shares common ancestry with differentiation pathways in land plants. Two homeoproteins, Gsp1 and Gsm1, contributed by gametes of plus and minus mating types respectively, physically interact and translocate from the cytosol to the nucleus upon gametic fusion, initiating zygote development. Their ectopic expression activates zygote development in vegetative cells and, in a diploid background, the resulting zygotes undergo a normal meiosis. Gsm1/Gsp1 dyads share sequence homology with and are functionally related to KNOX/BELL dyads regulating stem-cell (meristem) specification in land plants. We propose that combinatorial homeoprotein-based transcriptional control, a core feature of the fungal/animal radiation, may have originated in a sexual context and enabled the evolution of land-plant body plans.