Oxygenation of the Intraportally Transplanted Pancreatic Islet.
Oxygenation of the Intraportally Transplanted Pancreatic Islet.
复制标题
门静脉内移植胰岛的氧合。
DOI：
10.1155/2016/7625947
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发表时间：
2016
影响因子：
4.3
通讯作者：
Papas,KlearchosK
中科院分区：
文献类型：
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作者：
Suszynski,ThomasM;Avgoustiniatos,EfstathiosS;Papas,KlearchosK
门静脉内胰岛移植 (IT) 并未广泛用于治疗 1 型糖尿病。门静脉内移植胰岛的氧合尚未得到广泛研究。我们提出了一个扩散反应模型，该模型预测门静脉内移植胰岛中存在厌氧核心和更大的功能核心。研究了四个变量：胰岛直径、胰岛活力分数、外部氧分压 (P)（在门脉周围血液中）以及胰岛表面是否存在血栓。结果表明，具有平均大小和分数活力的胰岛在低外部 P 下表现出 14% 的缺氧体积分数 (AVF) 和 72% 的功能丧失。血栓形成使 AVF 增加至 30%，功能丧失至 92%，表明血栓形成的影响可能很大。外部胰岛直径对 AVF 和功能丧失的总体影响最大。在我们的机构中，大型人类 Alloislet（直径 >200μm）约占胰岛总数的 20%，但约占胰岛总体积的 70%；由于大部分移植胰岛总体积由大胰岛占据，因此大多数门脉内胰岛细胞可能缺氧且功能不全。
Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion‐reaction model that predicts the presence of ananoxiccore and a largerpartly functionalcore within intraportally transplanted islets. Four variables were studied: islet diameter, islet fractional viability, external oxygen partial pressure (P) (in surrounding portal blood), and presence or absence of a thrombus on the islet surface. Results indicate that an islet with average size and fractional viability exhibits an anoxic volume fraction (AVF) of 14% and a function loss of 72% at a low externalP. Thrombus formation increased AVF to 30% and function loss to 92%, suggesting that the effect of thrombosis may be substantial. ExternalPand islet diameter accounted for the greatest overall impact on AVF and loss of function. At our institutions, large human alloislets (>200μm diameter) account for ~20% of total islet number but ~70% of total islet volume; since most of the total transplanted islet volume is accounted for by large islets, most of the intraportal islet cells are likely to be anoxic and not fully functional.