BODY-WEIGHT AND FOOD-INTAKE AT EARLY ESTRUS OF RATS ON A HIGH-FAT DIET
BODY-WEIGHT AND FOOD-INTAKE AT EARLY ESTRUS OF RATS ON A HIGH-FAT DIET
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DOI：
10.1073/pnas.72.10.4172
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
YOSHINAGA, K
中科院分区：
文献类型：
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作者：
FRISCH, RE;HEGSTED, DM;YOSHINAGA, K
研究了两组断奶大鼠（21日龄）的体重、摄食量、阴道口和发情年龄，分别饲喂高脂（占体重的24.6%）和低脂（占体重的5.0%）饲料。在高脂肪饮食中，脂肪以等热量代替了碳水化合物。高脂大鼠的发情年龄为33.3 +/- 0.8 d，明显早于低脂大鼠的发情年龄（37.4 +/- 0.7 d） （P < 0.001）。81%的高脂肪大鼠的发情与阴道开放同时进行，而低脂肪大鼠的这一比例为48%。高脂大鼠和低脂大鼠在阴道口和发情期每100克体重的卡路里摄入量没有差异，而两组在年龄、体重、绝对食物摄入量（g/天）、相对食物摄入量（g/100克体重/天）和绝对卡路里摄入量（卡路里/天）方面都存在显著差异。高脂和低脂大鼠发情前，每100克体重的热量摄入随年龄的变化先增加后稳定下降。这些发现支持了肯尼迪的假设，即食物摄入信号（现在进一步定义为热量摄入/100克体重）是青春期的信号，并且与脂肪的关键身体组成对老鼠和人类女性的发情期至关重要的假设一致。
Body weight, food intake, and age at vaginal opening and estrus were studied for two groups of weanling rats (age 21 days), fed on high-fat (24.6% by weight) and low-fat (5.0%) diets. Fat was substituted isocalorically for carbohydrate in the high-fat diet. The high-fat rats had estrus at 33.3 +/- 0.8 days, significantly earlier (P less than 0.001) than the age at estrus, 37.4 +/- 0.7 days, of the low-fat rats. Estrus was simultaneous with vaginal opening in 81% of the high-fat rats, in comparison to 48% of the low-fat rats. The caloric intake per 100 g of body weight of the high-fat and low-fat rats did not differ at vaginal opening or at estrus, whereas the two groups differed significantly at both events in age, body weight, absolute food intake (g/day), and relative food intake (g/100 g of body weight per day) and absolute caloric intake (calories/day). Caloric intake/100 g of body weight as a function of chronological age first increased and then decreased steadily before estrus for both high-fat and low-fat rats. The findings support Kennedy's hypothesis that a food intake signal, now further defined as caloric intake/100 g of body weight, is a signal for puberty, and are in accord with the hypothesis that a critical body composition of fatness is essential for estrus in the rat, as in the human female.