Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.
Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.
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DOI：
10.3233/adr-220089
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发表时间：
2023
影响因子：
3.2
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
--
作者：
Ash, Sharon;Nevler, Naomi;Irwin, David J;Shellikeri, Sanjana;Rascovsky, Katya;Shaw, Leslie;Lee, Edward B;Trojanowski, John Q;Grossman, Murray
言语失用症（Apraxia of speech， AOS）是非流利/语法性原发性进行性失语症（naPPA）的核心特征，但其确切特征和AOS特征在自发性言语中的普遍存在争议。评估自发性连接性言语中AOS特征的频率，并评估这些特征是否与潜在的运动障碍（如皮质基底综合征或进行性核上性麻痹）有关。我们使用图片描述任务检查了30例naPPA患者的AOS特征。我们将这些患者与22名行为变异额颞叶痴呆患者和30名健康对照者进行了比较。每个语音样本在感知上评估了语音片段的延长，在定量上评估了语音失真、单词之间和单词内的停顿以及发音摸索。我们比较了具有或不具有至少两个AOS特征的naPPA亚组，以评估运动障碍对言语产生缺陷的可能贡献。naPPA患者出现语音扭曲和其他语音错误。在27/30（90%）的个体中发现了语音分割。有8/30（27%）的人出现了语音失真，有18/30（60%）的人出现了其他语音错误。在6/30（20%）的个体中观察到频繁的发音摸索。很少观察到延长的节段。在naPPA亚组之间，AOS特征的频率作为锥体外系疾病的功能没有差异。在naPPA患者的自发言语中，AOS的特征以不同的频率出现，独立于潜在的运动障碍。
Apraxia of speech (AOS) is a core feature of nonfluent/agrammatic primary progressive aphasia (naPPA), but its precise characteristics and the prevalence of AOS features in spontaneous speech are debated. To assess the frequency of features of AOS in the spontaneous, connected speech of individuals with naPPA and to evaluate whether these features are associated with an underlying motor disorder such as corticobasal syndrome or progressive supranuclear palsy. We examined features of AOS in 30 patients with naPPA using a picture description task. We compared these patients to 22 individuals with behavioral variant frontotemporal dementia and 30 healthy controls. Each speech sample was evaluated perceptually for lengthened speech segments and quantitatively for speech sound distortions, pauses between and within words, and articulatory groping. We compared subgroups of naPPA with and without at least two features of AOS to assess the possible contribution of a motor impairment to speech production deficits. naPPA patients produced both speech sound distortions and other speech sound errors. Speech segmentation was found in 27/30 (90%) of individuals. Distortions were identified in 8/30 (27%) of individuals, and other speech sound errors occurred in 18/30 (60%) of individuals. Frequent articulatory groping was observed in 6/30 (20%) of individuals. Lengthened segments were observed rarely. There were no differences in the frequencies of AOS features among naPPA subgroups as a function of extrapyramidal disease. Features of AOS occur with varying frequency in the spontaneous speech of individuals with naPPA, independently of an underlying motor disorder.