Synthesis of ß-keto esters in-flow and rapid access to substituted pyrimidines.
Synthesis of ß-keto esters in-flow and rapid access to substituted pyrimidines.
复制标题
α-酮酯的合成在流程中并快速获得取代的嘧啶。
DOI：
10.1021/jo101783m
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Bartrum HE
中科院分区：
文献类型：
--
作者：
Bartrum HE
我们开发了一种通过BF 3·OEt 2催化重氮乙酸乙酯在醛中的C-H插入反应合成β-酮酯的流程。然后将β-酮酯与一系列脒缩合，得到各种2，6-取代的嘧啶-4-醇。
We have developed an in-flow process for the synthesis of β-keto esters via the BF3·OEt2-catalyzed formal C−H insertion of ethyl diazoacetate into aldehydes. The β-keto esters were then condensed with a range of amidines to give a variety of 2,6-substituted pyrimidin-4-ols.