Disruption of the Borrelia burgdorferi gac gene, encoding the naturally synthesized GyrA C-terminal domain.
Disruption of the Borrelia burgdorferi gac gene, encoding the naturally synthesized GyrA C-terminal domain.
复制标题
伯氏疏螺旋体 gac 基因的破坏，编码天然合成的 GyrA C 末端结构域。
DOI：
10.1128/jb.182.7.2048-2051.2000
复制
发表时间：
2000
影响因子：
3.2
通讯作者：
Samuels,DS
中科院分区：
文献类型：
--
作者：
Knight,SW;Kimmel,BJ;Eggers,CH;Samuels,DS
The C-terminal domain of the A subunit of DNA gyrase, which we term Gac, is naturally synthesized inBorrelia burgdorferias an abundant DNA-binding protein. Full-length GyrA, which includes the C-terminal domain, is also synthesized by the spirochete and functions as a subunit of DNA gyrase. We have disrupted synthesis of Gac as an independent protein and demonstrated that it is not essential for growth in a coumarin-resistant background. We detected no alterations in DNA maintenance, condensation, or topology inB. burgdorferilacking this small DNA-binding protein.
