SYNTHESIS OF RABBIT BETA-GLOBIN IN CULTURED MONKEY KIDNEY CELLS FOLLOWING INFECTION WITH A SV40 BETA-GLOBIN RECOMBINANT GENOME
SYNTHESIS OF RABBIT BETA-GLOBIN IN CULTURED MONKEY KIDNEY CELLS FOLLOWING INFECTION WITH A SV40 BETA-GLOBIN RECOMBINANT GENOME
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DOI：
10.1038/277108a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
BERG, P
中科院分区：
文献类型：
--
作者：
MULLIGAN, RC;HOWARD, BH;BERG, P
Rabbit .beta.-globin complementary (c)DNA was inserted into SV-40 DNA in place of the gene coding for the virus'' major capsid protein, VP1. The recombinant genome, SVGT5-Ra.beta.G, multiplies efficiently in [African green monkey kidney] CV1 monkey kidney cell cultures and is transcribed to yield cytoplasmic, polyadenylated hybrid mRNA containing the .beta.-globin coding sequence. Cells propagating SVGT5-Ra.beta.G produce substantial quantities of rabbit .beta.-globin polypeptide.
