The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
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DOI：
10.1007/s00109-006-0139-0
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发表时间：
2007-05-01
影响因子：
4.7
通讯作者：
Pedersen, Oluf
中科院分区：
文献类型：
--
作者：
Jensen, Dorit P.;Andreasen, Camilla H.;Pedersen, Oluf
食物摄入量和体重增加受到内源性大麻素的影响，内源性大麻素的作用受脂肪酸酰胺水解酶(FAAH)的调节。编码FAAH的功能性Pro129Thr变异(Rs324420)的纯合子Thr/Thr基因型最近被报道与白人和黑人人群中的超重和肥胖有关。我们研究了Pro129Thr变异与超重和肥胖的关系，对丹麦白人(n=5,801)进行了相对较大的人群研究样本。在肥胖症的病例对照研究中，发现了与主要Pro等位基因的边缘关联；然而，在校正多重测试后，没有发现关联。此外，肥胖相关数量性状的研究不支持主要Pro等位基因与肥胖之间可能的关联。总而言之，在一个大的研究样本中，我们无法找到强有力的证据表明Pro129Thr FAAH变异与受检白人中的超重、肥胖和任何相关的数量性状有关。
Food intake and weight gain are influenced by endocannabinoids whose actions are regulated by the fatty acid amide hydrolase (FAAH) enzyme. The homozygous Thr/Thr genotype of the functional Pro129Thr variant (rs324420) in the gene encoding FAAH was recently reported to associate with overweight and obesity in white and black populations. We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801). In case-control studies of obesity, a borderline association with the major Pro allele was identified; however, after correction for multiple testing, no association was found. Furthermore, a possible association between the major Pro allele and obesity was not supported by studies of obesity-related quantitative traits. In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites.