Blueprint for building a biorepository in a resource-limited setting that follows international best practices
Blueprint for building a biorepository in a resource-limited setting that follows international best practices
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DOI：
10.4102/ajlm.v8i1.722
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发表时间：
2019-01-01
影响因子：
1.1
通讯作者：
Beiswanger, Christine M.
中科院分区：
文献类型：
--
作者：
Abimiku, Alash'le G.;Croxton, Talishea;Beiswanger, Christine M.
背景：非洲大陆具有丰富的遗传多样性。然而，由于缺乏高质量和广泛注释的生物标本以及支持这种技术密集型努力的必要基础设施，基因组研究一直受到阻碍。目的：尼日利亚人类病毒学研究所(IHVN)与H3非洲联盟和科里尔医学研究所合作，建立一个国际公认的生物资料库，用于生物医学研究生物标本的接收、处理、储存和分发。结果：确定了高质量生物储存库的关键要求：(1)基础设施和服务的机构支持，(2)对生物储存库的主要承诺的现场培训工作人员，(3)依赖全球公认的生物储存库组织的最佳做法，(4)及早实施质量管理系统，(5)采用功能多样的实验室信息管理系统，(6)与外部专家合作，通过摘要、通讯、出版手稿以及出席会议和研讨会分享经验，(7)严格遵守地方和国家的道德标准；(8)每年审查和更新的可持续发展计划。结论：以发表的全球公认的生物信息库领域专家的最佳实践为基准，IHVN扩展和重组了现有的实验室设施和工作人员，以实现这一新目的。
Background: Genetic diversity is abundant on the African continent. However, genomic research has been hampered by a lack of high quality and extensively annotated biospecimens and the necessary infrastructure to support such a technology-intensive effort.Objective: The Institute of Human Virology Nigeria (IHVN) partnered with the H3Africa Consortium and the Coriell Institute for Medical Research to build an internationally recognised biorepository for the receipt, processing, storage and distribution of biospecimens for biomedical research. Here, the authors describe the procedures, challenges and results encountered.Results: Key requirements for a high-quality biorepository were identified: (1) institutional support of infrastructure and services, (2) on-site trained staff with primary commitment to the biorepository, (3) reliance on best practices from globally recognised biorepository groups, (4) early implementation of a quality management system, (5) adoption of a laboratory information management system with demonstrated versatility in functions, (6) collaboration with external experts and sharing of experience through abstracts, newsletters, published manuscripts, and attendance at meetings and workshops, (7) strict adherence to local and national ethical standards and (8) a sustainability plan that is reviewed and updated annually.Conclusion: Utilising published best practices of globally recognised experts in the biorepository field as a benchmark, IHVN expanded and reorganised its existing laboratory facility and staff to take on this new purpose.