A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni
A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni
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DOI：
10.1016/j.vetimm.2019.109985
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发表时间：
2020-01-01
影响因子：
1.8
通讯作者：
Guigal, P. M.
中科院分区：
文献类型：
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作者：
Bouvet, J.;Lemaitre, L.;Guigal, P. M.
先前证实了多价疫苗DAPPi-L的钩端螺旋体组分对三种问号钩端螺旋体血清型的毒力攻击的效力在本研究中，我们证明了这种疫苗在接种后两周提供了额外的保护，（预防死亡、临床症状、肾脏感染、细菌排泄、肾脏携带和肾脏损害）对抗由钩端螺旋体血清型Copenhageni（具有重要医学意义的血清型）引起的致死性钩端螺旋体病。
Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination.In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).