A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects
A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects
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DOI：
10.1007/s00406-019-00978-2
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发表时间：
2019-02-01
影响因子：
4.7
通讯作者：
Croft, Rodney
中科院分区：
文献类型：
--
作者：
Solowij, Nadia;Broyd, Samantha;Croft, Rodney
全世界越来越多地获得大麻和大麻素产品用于娱乐和医疗用途。大麻植物物质中的两种主要化合物，Delta（9）-四氢大麻酚（THC）和大麻二酚（CBD）都是精神活性物质，但只有THC被认为是令人陶醉的。人们对这些大麻素和CBD的潜在治疗特性特别感兴趣。一些研究表明，CBD可能会改善THC的不良影响，但这可能是剂量依赖性的，因为其他证据表明，低剂量的CBD可能会增强THC的影响。我们进行了一项随机安慰剂对照试验，以检查这些化合物单独和联合使用时，通过蒸发频繁和不频繁的大麻用户的急性影响。参与者（n = 36; 31名男性）完成了间隔一周的5种药物条件，并进行了以下计划对比：安慰剂与单独的CBD（400 mg）;单独的THC（8 mg）与THC结合低（4 mg）或高（400 mg）剂量的CBD。中毒的客观（盲观察者评级）和主观（自评）措施是主要结果，与其他指标的中毒检查。相对于安慰剂，CBD显示出一些令人陶醉的特性。低剂量的CBD与THC结合时增强，而高剂量的CBD降低了THC的致醉作用。低剂量CBD的中毒增强在不频繁的大麻使用者中特别突出，并且在客观和主观测量中是一致的。大多数效应在p
Access to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), are both psychoactive, but only THC is considered intoxicating. There is significant interest in potential therapeutic properties of these cannabinoids and of CBD in particular. Some research has suggested that CBD may ameliorate adverse effects of THC, but this may be dose dependent as other evidence suggests possible potentiating effects of THC by low doses of CBD. We conducted a randomised placebo controlled trial to examine the acute effects of these compounds alone and in combination when administered by vaporisation to frequent and infrequent cannabis users. Participants (n = 36; 31 male) completed 5 drug conditions spaced one week apart, with the following planned contrasts: placebo vs CBD alone (400 mg); THC alone (8 mg) vs THC combined with low (4 mg) or high (400 mg) doses of CBD. Objective (blind observer ratings) and subjective (self-rated) measures of intoxication were the primary outcomes, with additional indices of intoxication examined. CBD showed some intoxicating properties relative to placebo. Low doses of CBD when combined with THC enhanced, while high doses of CBD reduced the intoxicating effects of THC. The enhancement of intoxication by low-dose CBD was particularly prominent in infrequent cannabis users and was consistent across objective and subjective measures. Most effects were significant at p