Brain regulation of food craving: relationships with weight status and eating behavior
Brain regulation of food craving: relationships with weight status and eating behavior
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DOI：
10.1038/ijo.2016.28
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发表时间：
2016-06-01
影响因子：
4.9
通讯作者：
Horstmann, A.
中科院分区：
文献类型：
--
作者：
Dietrich, A.;Hollmann, M.;Horstmann, A.
食欲：对食物的渴望是暴饮暴食和肥胖的驱动力。然而，参与其调节的大脑机制与体重状态之间的关系仍然是一个悬而未决的问题。研究的体重指数（BMI）分布的差距和对线性分析的关注可能导致了这种知识的缺乏。在这里，我们研究了大脑机制的渴望调节功能磁共振成像在一个平衡的样本，包括正常体重，超重和肥胖的参与者。我们研究了肥胖、饮食行为和调节脑功能的特征之间的关系，重点是非线性关系。根据美味度和健康度分别预先评定视觉食物刺激。我们分析了调节性大脑活动以及功能连接与BMI或饮食行为之间的关系（三因素饮食问卷，量表：认知抑制，去抑制）。结果：在调节过程中，BMI与左壳核、杏仁核和杏仁核的大脑活动呈倒U形相关。壳核和背外侧前额叶皮层（dlPFC）之间的功能连接与BMI呈正相关，而杏仁核与苍白球和舌回的非线性（U形）与BMI相关。去抑制与杏仁核和背内侧前额叶（dmPFC）皮质以及caudate.CONCLUSIONS：这项研究是第一次揭示二次关系的食物相关的大脑过程和BMI之间的功能连接的强度呈负相关。报告的非线性协会表示与肥胖范围相比，在正常体重/超重的范围内的调节相关的动机处理之间的反比关系。连通性分析表明，需要自上而下（dlPFC）调整纹状体的值表示与BMI增加，而自我监控（dmPFC）或饮食相关的战略行动计划（尾状核）和显着性处理（杏仁核）的相互作用可能会受到阻碍与高去抑制。
OBJECTIVES: Food craving is a driving force for overeating and obesity. However, the relationship between brain mechanisms involved in its regulation and weight status is still an open issue. Gaps in the studied body mass index (BMI) distributions and focusing on linear analyses might have contributed to this lack of knowledge. Here, we investigated brain mechanisms of craving regulation using functional magnetic resonance imaging in a balanced sample including normal-weight, overweight and obese participants. We investigated associations between characteristics of obesity, eating behavior and regulatory brain function focusing on nonlinear relationships.SUBJECTS/METHODS: Forty-three hungry female volunteers (BMI: 19.4-38.8 kg m(-2), mean: 27.5 +/- 5.3 s.d.) were presented with visual food stimuli individually pre-rated according to tastiness and healthiness. The participants were instructed to either admit to the upcoming craving or regulate it. We analyzed the relationships between regulatory brain activity as well as functional connectivity and BMI or eating behavior (Three-Factor Eating Questionnaire, scales: Cognitive Restraint, Disinhibition).RESULTS: During regulation, BMI correlated with brain activity in the left putamen, amygdala and insula in an inverted U-shaped manner. Functional connectivity between the putamen and the dorsolateral prefrontal cortex (dlPFC) correlated positively with BMI, whereas that of amygdala with pallidum and lingual gyrus was nonlinearly (U-shaped) associated with BMI. Disinhibition correlated negatively with the strength of functional connectivity between amygdala and dorsomedial prefrontal (dmPFC) cortex as well as caudate.CONCLUSIONS: This study is the first to reveal quadratic relationships of food-related brain processes and BMI. Reported nonlinear associations indicate inverse relationships between regulation-related motivational processing in the range of normal weight/overweight compared with the obese range. Connectivity analyses suggest that the need for top-down (dlPFC) adjustment of striatal value representations increases with BMI, whereas the interplay of self-monitoring (dmPFC) or eating-related strategic action planning (caudate) and salience processing (amygdala) might be hampered with high Disinhibition.