A Quantitative Meta-Analysis on Cue-Induced Male Sexual Arousal
A Quantitative Meta-Analysis on Cue-Induced Male Sexual Arousal
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DOI：
10.1111/j.1743-6109.2011.02322.x
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发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Gallinat, Juergen
中科院分区：
文献类型：
--
作者：
Kuhn, Simone;Gallinat, Juergen
导言。视觉诱导性唤起是人类行为中常见的现象。这种反应的大脑基础已经在最近的神经成像研究中得到了探索。我们开始测试证据的强度，证明大脑区域的核心网络参与了性爱刺激引起的男性性唤起。11项功能磁共振成像研究显示了色情视觉刺激，并将相关的大脑活动与中性视觉刺激引发的大脑活动进行了比较。主要结果衡量标准。使用激活似然估计对大脑激活坐标进行定量荟萃分析，以评估研究之间的显著一致性。荟萃分析包括对异性恋男性的研究，发现在所有研究中，下丘脑、丘脑、杏仁核、扣带回前回、岛叶、梭形回、中央前回、顶叶皮质和枕叶皮质的激活一致。此外，我们还探索了与性唤醒的一个生理标志(阴茎肿胀)相关的大脑反应，发现下丘脑、丘脑、双侧脑岛、ACC、中央后回和枕回同时存在。这是首次对性暗示反应性进行定量的荟萃分析，确定了由认知(顶叶皮质、ACC、丘脑、脑岛)、情绪(杏仁核、脑岛)、动机(中央前回、顶叶皮质)和生理(下丘脑/丘脑、脑岛)组成的神经网络，构成了人类男性性唤起的核心回路。库恩·S和加里纳特·J.线索诱导男性性唤起的定量荟萃分析。J Sex Med 2011；8：2269-2275。
Introduction. Visually induced sexual arousal is a common occurrence in human behavior. The cerebral underpinnings of this response have been explored in recent neuroimaging studies.Aim. We set out to test the strength of evidence for the presence of a core network of brain regions involved in male sexual arousal elicited by erotic stimuli.Methods. Eleven functional magnetic resonance imaging studies that presented erotic visual stimuli and compared the associated brain activity with the brain activity elicited by neutral visual stimuli were identified.Main Outcomes Measures. Activation likelihood estimation was employed to perform quantitative meta-analyses on coordinates of brain activation in order to assess significant concordance across studies.Results. The meta-analysis included studies on heterosexual males and revealed consistent activation in the hypothalamus, thalamus, amygdala, anterior cingulate gyrus (ACC), insula, fusiform gyrus, precentral gyrus, parietal cortex, and occipital cortex across studies. Moreover, we explored brain responses associated with a physiological marker of sexual arousal (penile tumescence) and found concurrence in hypothalamus, thalamus, bilateral insula, ACC, postcentral gyrus, and occipital gyrus.Conclusions. This is the first quantitative meta-analysis on sexual cue reactivity and identifies a neural network consisting of cognitive (parietal cortex, ACC, thalamus, insula), emotional (amygdala, insula), motivational (precentral gyrus, parietal cortex), and physiological (hypothalamus/thalamus, insula) components constituting a core circuit of male sexual arousal in humans. Kuhn S and Gallinat J. A quantitative meta-analysis on cue-induced male sexual arousal. J Sex Med 2011;8:2269-2275.