Multifaceted Roles of Ferroptosis in Lung Diseases.
Multifaceted Roles of Ferroptosis in Lung Diseases.
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DOI：
10.3389/fmolb.2022.919187
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
Ferroptosis是一种不同类型的程序性细胞死亡（PCD），它依赖于铁，其特征是细胞内铁的积累、谷胱甘肽的耗尽、谷胱甘肽过氧化物酶的失活和脂质过氧化的促进。近年来，越来越多的研究表明，铁下垂与许多肺部疾病的发生和发展密切相关。在这篇综述中，我们总结了上铁对肺部疾病病理过程的贡献，包括阻塞性肺疾病（慢性阻塞性肺疾病、哮喘和囊性纤维化）、间质性肺疾病（不同原因的肺纤维化）、血管源性肺疾病（缺血-再灌注损伤和肺动脉高压）、肺部感染（细菌、病毒和真菌）、急性肺损伤、急性呼吸窘迫综合征、阻塞性睡眠呼吸暂停，肺泡蛋白沉积症和肺癌。我们还讨论了靶向铁下垂治疗这些肺部疾病的潜力。
Ferroptosis is a distinct type of programmed cell death (PCD) that depends on iron and is characterized by the accumulation of intracellular iron, exhaustion of glutathione, deactivation of glutathione peroxidase, and promotion of lipid peroxidation. Recently, accumulated investigations have demonstrated that ferroptosis is strongly correlated with the initiation and development of many lung diseases. In this review, we summarized the contribution of ferroptosis to the pathologic process of lung diseases, namely, obstructive lung diseases (chronic obstructive pulmonary disease, asthma, and cystic fibrosis), interstitial lung diseases (pulmonary fibrosis of different causes), pulmonary diseases of vascular origin (ischemia-reperfusion injury and pulmonary hypertension), pulmonary infections (bacteria, viruses, and fungi), acute lung injury, acute respiratory distress syndrome, obstructive sleep apnea, pulmonary alveolar proteinosis, and lung cancer. We also discussed the therapeutic potential of targeting ferroptosis for these lung diseases.
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