Gestational risk factors and childhood cancers: A cohort study in Taiwan
Gestational risk factors and childhood cancers: A cohort study in Taiwan
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DOI：
10.1002/ijc.32905
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发表时间：
2020-02-17
影响因子：
6.4
通讯作者：
Li, Chung-Yi
中科院分区：
文献类型：
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作者：
Heck, Julia E.;Lee, Pei-Chen;Li, Chung-Yi
出生体重、胎龄和产次等妊娠风险因素已被反复发现与儿科癌症有关，但亚洲国家的报告很少。在这里，我们报告的人口和妊娠因素在台湾的队列。我们的研究包括2004-2014年在台湾出生的所有有出生记录的儿童（n = 2，079，037），其中1900名儿童在12岁之前被诊断患有癌症。我们进行了多变量风险回归，以检查人口统计学和妊娠因素与癌症之间的关联。较大产次（有2+大龄儿童的家庭）与急性髓性白血病[风险比（HR）= 2.15，95%置信区间（CI）：1.31，3.55）、中枢神经系统肿瘤（HR = 1.67，CI：1.13，2.48）和神经母细胞瘤（HR = 1.67，CI：1.07，2.63）相关。肝母细胞瘤病例有较高的低出生体重风险（
Gestational risk factors such as birth weight, gestational age and parity have been repeatedly found to be related to pediatric cancers, but few reports have emerged from Asian countries. Here we report on demographic and gestational factors in a Taiwanese cohort. Our study included all children born in Taiwan 2004-2014 for whom there was a birth record (n = 2,079,037), of which 1900 children had been diagnosed with cancer prior to age 12. We conducted multivariable hazard regression to examine associations between demographic and gestational factors with cancer. Greater parity (family with 2+ older children) was related to acute myeloid leukemia [Hazard ratio (HR) = 2.15, 95% confidence interval (CI): 1.31, 3.55), central nervous system tumors (HR = 1.67, CI: 1.13, 2.48) and neuroblastoma (HR = 1.67, CI: 1.07, 2.63). Hepatoblastoma cases had a higher risk of low birth weight (