11Beta-hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites.
11Beta-hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites.
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11β-羟基类固醇脱氢酶 2 型和地塞米松代谢物对表面活性蛋白 A 的调节。
DOI：
10.1152/ajpendo.00396.2005
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Snyder,JeanneM
中科院分区：
文献类型：
--
作者：
Garbrecht,MarkR;Schmidt,ThomasJ;Krozowski,ZygmuntS;Snyder,JeanneM
Glucocorticoid (GC) metabolism by the 11β-hydroxysteroid dehydrogenase (HSD) system is an important prereceptor regulator of GC action. The HSD enzymes catalyze the interconversion of the endogenous, biologically active GC cortisol and its inactive 11-dehydro metabolite cortisone. The role of the HSD enzymes in the metabolism of synthetic GCs, such as dexamethasone (Dex), is more complex. The human lung is a classic GC-sensitive organ; however, the roles of the HSD enzymes (HSD1 and HSD2) in the human lung are poorly understood. In the present study, we examined the expression of the HSD enzymes in human adult and fetal lung tissues and the human lung epithelial cell line NCI-H441. We observed that human adult and fetal lung tissues, as well as H441 cells, express HSD2 protein and that it is upregulated by Dex (10−7M). By contrast, HSD1 protein was undetectable. We also show that the Dex-mediated regulation of surfactant protein A is attenuated by inhibition of HSD2 activity. Furthermore, we demonstrate that unlike the inactive, 11-dehydro metabolite of cortisol (i.e., cortisone), the 11-dehydro metabolite of Dex, 11-dehydro-Dex, competes for binding to the GC receptor (GR) in human lung epithelial cells and retains GR agonist activity. Together, these data suggest that differences exist in the biological activities of the metabolites of cortisol and Dex.
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影响因子：
4.8
作者：
Odom,MJ;Snyder,JM;Boggaram,V;Mendelson,CR
通讯作者：
Mendelson,CR
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影响因子：
9.8
作者：
S. Ramin;A. Vidaeff;L. Gilstrap;K. Bishop;G. Jenkins;J. Alcorn
通讯作者：
J. Alcorn
多个疗程的产前类固醇：风险和益处
影响因子：
7.2
作者：
A. Walfisch;M. Hallak;M. Mazor
通讯作者：
M. Mazor
甘苯索隆对大鼠体内肾 11β-羟基类固醇脱氢酶的抑制及其与钠排泄的关系。
影响因子：
6
作者：
Kj Sewell;D.;AE Michael;A. Thompson;D. Norgate;Robert J. Unwin
通讯作者：
Robert J. Unwin
DOI：
10.1152/ajplung.00280.2003
发表时间：
2004-04-01
影响因子：
4.9
作者：
Alcorn, JL;Islam, KN;Mendelson, CR
通讯作者：
Mendelson, CR