Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue.
Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue.
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DOI：
10.1021/ol006993n
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发表时间：
2001-03
期刊：
影响因子：
5.2
通讯作者：
J. Niles;J. Wishnok;S. Tannenbaum
中科院分区：
文献类型：
--
作者：
J. Niles;J. Wishnok;S. Tannenbaum
[反应：见正文]。强氧化剂过氧亚硝酸盐将氧化8-氧代-7，8-二氢鸟苷，得到几种产物。在硫醇试剂的存在下，主要的最终产物已被确定为螺亚氨基二乙内酰脲化合物。此外，我们发现螺亚氨基二乙内酰脲，而不是以前报道的4-羟基-8-氧代-4，8-二氢鸟苷，是在亚甲蓝介导的鸟苷光氧化过程中形成的主要最终产物。
[reaction: see text]. The potent oxidant, peroxynitrite, will oxidize 8-oxo-7,8-dihydroguanosine to give several products. In the presence of a thiol agent, the major final product has been determined to be a spiroiminodihydantoin compound. Additionally, we have found that the spiroiminodihydantoin, and not the previously reported 4-hydroxy-8-oxo-4,8-dihydroguanosine, is the major final product formed during the methylene blue-mediated photooxidation of guanosine.