Pulmonary disorders: ventilation-perfusion MR imaging with animal models.
Pulmonary disorders: ventilation-perfusion MR imaging with animal models.
复制标题
肺部疾病：动物模型的通气-灌注磁共振成像。
DOI：
10.1148/radiology.213.3.r99dc31871
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Edelman,RR
中科院分区：
文献类型：
--
作者：
Chen,Q;Levin,DL;Kim,D;David,V;McNicholas,M;Chen,V;Jakob,PM;Griswold,MA;Goldfarb,JW;Hatabu,H;Edelman,RR
PURPOSE:To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism.MATERIALS AND METHODS:Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine.RESULTS:Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli.CONCLUSION:Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.
