Glycemic Variability and Its Association With Demographics and Lifestyles in a General Adult Population.
Glycemic Variability and Its Association With Demographics and Lifestyles in a General Adult Population.
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DOI：
10.1177/1932296816682031
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发表时间：
2017-07-01
影响因子：
5
通讯作者：
Gonzalez-Quintela, Arturo
中科院分区：
文献类型：
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作者：
Gude, Francisco;Diaz-Vidal, Pablo;Gonzalez-Quintela, Arturo
目的：目的是调查血糖变异指数与人口因素和常见的环境生活方式在一般成年population.METHODS：埃斯特拉达糖化和炎症研究是一个横断面研究，包括1516名参与者的抽样年龄在18岁及以上的人口。622人的子样本参与了糖化项目，其中包括连续葡萄糖监测程序。五个血糖变异性指数进行了分析，即，SD，法师，MAG，CONGA 1，和MODD.RESULTS：参与者的平均年龄为48岁，62%是女性，和12%以前被诊断为糖尿病。在无糖尿病的人群中，指数分布不是正态分布，而是向右倾斜。调整年龄，性别，BMI，酒精摄入量，吸烟状况和体力活动的分布回归模型证实，所有指标与空腹血糖水平呈正相关，与重度饮酒呈负相关。SD、法师和CONGA 1与年龄呈正相关，MAG与BMI呈负相关。研究的GVI都没有受到身体活动的影响。的index.CONCLUSIONS：这项研究产生了特定年龄的参考值葡萄糖变异性指数在一般成人人群。随着年龄的增长，观察到显着增加。超过140克/周的大量饮酒与变异性指数的显着下降相关。未发现雄性和雌性之间存在差异。这些标准范围为临床护理提供了指导，并可能为糖尿病患者提供替代治疗目标。
OBJECTIVE: The objective was to investigate glycemic variability indices in relation to demographic factors and common environmental lifestyles in a general adult population.METHODS: The A Estrada Glycation and Inflammation Study is a cross-sectional study covering 1516 participants selected by sampling of the population aged 18 years and over. A subsample of 622 individuals participated in the Glycation project, which included continuous glucose monitoring procedures. Five glycemic variability indices were analyzed, that is, SD, MAGE, MAG, CONGA1, and MODD.RESULTS: Participants had a mean age of 48 years, 62% were females, and 12% had been previously diagnosed with diabetes. In the population without diabetes, index distributions were not normal but skewed to the right. Distributional regression models that adjusted for age, gender, BMI, alcohol intake, smoking status, and physical activity confirmed that all indices were positively and independently associated with fasting glucose levels and negatively with heavy drinking. SD, MAGE, and CONGA1 were positively associated with aging, and MAG was negatively associated with BMI. None of the GVI studied were influenced by physical activity. Age-group-specific reference values are given for the indices.CONCLUSIONS: This study yielded age-specific reference values for glucose variability indices in a general adult population. Significant increases were observed with aging. Heavy drinking of more than 140 g/week was associated with significant decreases in variability indices. No differences were found between males and females. These normative ranges provide a guide for clinical care, and may offer an alternative treatment target among persons with diabetes.