Newborn and adult face shapes related to mouse cleft lip predisposition.
Newborn and adult face shapes related to mouse cleft lip predisposition.
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新生儿和成人面部形状与小鼠唇裂倾向相关。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Machado
中科院分区：
文献类型：
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作者：
D. Trasler;M. Machado
由于A/J小鼠与C57 BL/6（抗性胚胎）不同，因此假定胚胎面部形状是A/J小鼠唇裂（CL）易感性的多因素基础中的一个因素。为了验证这一假设，通过选择创建了新系并测量了胚胎（Juriloff和Trasler，1976年）。具有9%CL的L系具有如A/J（12%CL）的预测的窄鼻间窝距离，与如抗性C57 BL/6（0%CL）的M系（0%CL）相比。测量这四个品系的新生儿和成年人以及CL/Fr（23%CL），以发现它们是否像胚胎一样具有与它们的CL倾向相关的面部形状。对新生儿和2个半月大的小鼠头骨和固定软组织的头部进行测量。CL线CL/Fr、A/J和L的新生儿和成人前上颌骨长度（PL，从切牙孔到腭前孔前缘的距离）显著短于非CL线M和C57 BL/6。成人前颌骨宽度（除A/J外）有变窄的趋势，新生儿和成人牙龈（即滤骨）长度（GL）在CL线上有变短的趋势。判别分析成人骨骼数据包括四个变量PL，PW，眶间距离（ID）和鼻骨长度（LN）区分A/J和L从M和C57 BL/6线。省略ID的判别分析将CL系A/J、L和CL/Fr与非CL系M和C57区分开。判别分析对新生儿颅骨PL、LN和ID的判别能力较差，但对A/J和L与C57和M的判别能力较强。因此，一个特定的面部复杂的CL易感性已被发现。
Embryonic face shape was postulated to be a factor in the multifactorial basis for susceptibility to cleft lip (CL) in A/J mice, since A/J differed from C57BL/6 (resistant embryos). To test this hypothesis new lines were created by selection and the embryos measured (Juriloff and Trasler, 1976). The L line with 9% CL had the predicted narrow internasal pit distance like A/J (12% CL) compared to the M line (0% CL) like the resistant C57BL/6 (0% CL). Newborns and adults of these four lines and CL/Fr (23% CL) were measured to find whether they, like embryos, have face shapes related to their CL predisposition. Measurements were made on newborn and 2 1/2 month old mouse skulls and on heads fixed for soft tissue. Premaxilla length (PL, distance from incisive foramen to anterior edge of anterior palatine foramen) was significantly shorter in newborns and adults in CL lines CL/Fr, A/J and L than non-CL lines M and C57BL/6. Premaxilla width (PW) tended to be narrower in adults (except A/J) and gum (i.e. filtrum) length (GL) in newborns and adults tended to be shorter in CL lines. Discriminant analysis of adult skeletal data involving four variables PL, PW, Interorbital distance (ID) and length of nasal bones (LN) discriminated A/J and L from M and C57BL/6 lines. Discriminant analysis with ID omitted discriminated CL lines A/J, L and CL/Fr from non-CL lines M and C57. For variables PL, LN and ID in newborn skulls discriminant analysis had less discriminating ability, but showed a strong tendency to separate A/J and L from C57 and M. Thus a particular facial complex associated with CL predisposition has been found.