Distribution of Ia-like molecules on the surface of normal and leukemic human cells.
Distribution of Ia-like molecules on the surface of normal and leukemic human cells.
复制标题
Ia 样分子在正常和白血病人类细胞表面的分布。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
J. Strominger
中科院分区：
文献类型：
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作者：
S. Schlossman;L. Chess;R. Humphreys;J. Strominger
从人淋巴母细胞样B细胞系中分离和纯化的23，000和30，000道尔顿亚基（p23，30）糖蛋白抗原复合物的抗血清显示对人囊等价加工（B）细胞具有高度特异性，与15-20%的人胸腺细胞反应，但与人胸腺加工（T）细胞完全不反应。p23，30抗原广泛分布于慢性淋巴细胞白血病细胞、85%的急性淋巴细胞白血病细胞、所有急性粒细胞白血病细胞上，但不分布于慢性粒细胞白血病细胞上。还制备了一种对正常人胸腺细胞特异的兔抗血清，它仅与表面无p23，30的急性淋巴白血病细胞亚群（15%）反应。
Antiserum to a glycoprotein antigen complex of 23,000 and 30,000 dalton subunits (p23,30), isolated and purified from a human lymphoblastoid B cell line, was shown to be highly specific for human bursal-equivalent-processed (B) cells, reactive with 15-20% of human Null cells, but completely unreactive with human thymus-processed (T) cells. The p23,30 antigen is widely distributed on chronic lymphatic leukemic cells, 85% of acute lymphatic leukemic cells, all acute myelogenous leukemic cells, but not on chronic myelogenous leukemic cells. A rabbit antiserum specific for normal human thymocytes has also been prepared; it is reactive only with precisely that subset of acute lymphatic leukemic cells (15%) whose members do not have p23,30 on their surfaces.