Abnormal selective attention normalizes P3 amplitudes in PDD
Abnormal selective attention normalizes P3 amplitudes in PDD
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DOI：
10.1007/s10803-006-0102-5
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发表时间：
2006-07-01
影响因子：
3.9
通讯作者：
van Engeland, Herman
中科院分区：
文献类型：
--
作者：
Hoeksma, Marco R.;Kemner, Chantal;van Engeland, Herman
本研究旨在探讨PDD中P3波幅异常是否是视觉和听觉任务中与选择性注意相关的ERP成分异常的必然结果。此外，本研究试图澄清这些异常中可能存在的年龄差异。与对照组相比，PDD儿童P3波幅较小，但选择性注意无异常。PDD青少年表现出异常的选择性注意，如较大的听觉加工负性（PN）和视觉N2b所反映的，但没有P3异常。偶极子定位显示，与PDD受试者的PN发生器的位置与对照不同。结论：PDD青少年的选择性注意异常对P3有正常化作用，可能是一种代偿过程。
This paper studied whether abnormal P3 amplitudes in PDD are a corollary of abnormalities in ERP components related to selective attention in visual and auditory tasks. Furthermore, this study sought to clarify possible age differences in such abnormalities. Children with PDD showed smaller P3 amplitudes than controls, but no abnormalities in selective attention. Adolescents with PDD showed abnormal selective attention, as reflected by larger auditory Processing Negativity (PN) and visual N2b, but no P3 abnormalities. Dipole localizations revealed that the locations of PN generators in subjects with PDD differed from controls. It was concluded that the abnormalities in selective attention in adolescents with PDD have a normalizing effect on P3, and possibly act as a compensatory process.