LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF UNANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH
LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF UNANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH
复制标题
DOI：
10.1113/jphysiol.1973.sp010274
复制
发表时间：
1973-01-01
影响因子：
5.5
通讯作者：
GARDNERM.AR
中科院分区：
文献类型：
--
作者：
BLISS, TVP;GARDNERM.AR
1. 在长期制备的未麻醉家兔的海马结构齿状区记录了由穿孔通路刺激引起的电位变化。2. 颗粒细胞群中的兴奋性突触电流和动作电位成分是可区分的，其特征与麻醉兔大致相同。3. 以15/秒的速度刺激几秒钟，通常会导致颗粒细胞被单个刺激更有效地激活（“频率增强”）。单一刺激通常会在颗粒细胞群中产生多次放电。4. 在15/秒的单次刺激15-20秒后，26%的情况下（其中41%有良好的频率增强）对后续刺激的反应有持久的增强，持续时间从1小时到3天。5. 再经过20%的重复刺激后，会出现较短的持续增强，而经过8%的重复刺激后，会出现短暂的持续抑郁。6. 当这种增强作用出现时，其特征表现为以下几种或全部变化：突触波和群体尖峰的振幅增加，群体尖峰的潜伏期减少，群体尖峰特征的可变性减少。7. 在长时间的增强过程中，突触后细胞的兴奋性增加，在某些情况下，但不是所有情况下，由突触作用直接产生的细胞外电流增加。
1. Potential changes evoked by stimulation of the perforant path have been recorded in the dentate area of the hippocampal formation in chronically prepared unanaesthetized rabbits. 2. Components attributed to excitatory synaptic current flow and to action potentials in the granule cell population were distinguishable, with characteristics largely the same as in anaesthetized rabbits. 3. Stimulation at 15/sec for several seconds usually led to the granule cells being more effectively activated by the individual stimuli of the train (`frequency potentiation'). Single stimuli then commonly produced multiple discharges in the granule cell population. 4. After single periods of stimulation at 15/sec for 15-20 sec there was on 26% of the occasions (41% of those on which there was good frequency potentiation) a long-lasting potentiation of the responses to subsequent stimuli, lasting from 1 hr to 3 days. 5. After a further 20% of the periods of repetitive stimulation there was a shorter lasting potentiation, and after 8% there was a short lasting depression. 6. The potentiation, when present, was characterized by some or all of the following changes: increases in the amplitudes of the synaptic wave and population spike, reduction in the latency of the population spike, and reductions in the variability of the characteristics of the population spike. 7. During the long-lasting potentiation there was an increase in the excitability of the post-synaptic cells and, on some but not all occasions, an increase in the extracellular current flow produced directly by synaptic action.