A Prospective Study of Sleep Duration and Pneumonia Risk in Women
A Prospective Study of Sleep Duration and Pneumonia Risk in Women
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DOI：
10.5665/sleep.1594
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发表时间：
2012-01-01
期刊：
影响因子：
5.6
通讯作者：
Fawzi, Wafaie W.
中科院分区：
文献类型：
--
作者：
Patel, Sanjay R.;Malhotra, Atul;Fawzi, Wafaie W.
研究目的：实验数据表明睡眠剥夺可能损害宿主免疫力。我们试图评估睡眠不佳对肺炎风险的影响。设计：前瞻性，观察性队列研究。参与者：56，953名女护士（年龄37至57岁）参加护士健康研究II队列，无癌症、心血管疾病、糖尿病和哮喘，既往无肺炎史。在基线时，参与者报告了他们的平均睡眠时间以及这个数量对他们来说是否足够。每两年邮寄一次确定新肺炎诊断的病历。病例需要医生诊断和胸片确认。考克斯比例风险模型被用来评估4年内发生肺炎的相对风险。超过217，500人-年，确定了977例肺炎病例。相对于8小时睡眠者，短时间和长时间睡眠都与肺炎风险升高相关。睡眠≥ 9小时的受试者经年龄校正的肺炎相对危险度为1.70（95%CI 1.30-2.23）。校正潜在混杂因素后，睡眠≥ 9 h的相对风险为1.39（95%CI：1.06-1.82）。在多变量模型中，认为睡眠不足也与肺炎相关，相对危险度为1.50（95%CI 1.29-1.74）。结论：减少和延长习惯性睡眠时间与肺炎风险增加相关。需要进一步的研究来了解睡眠习惯如何影响免疫力。
Study Objective: Experimental data suggest sleep deprivation may impair host immunity. We sought to assess the effect of poor sleep on pneumonia risk.Design: Prospective, observational cohort study.Participants: 56,953 female nurses (ages 37 to 57 years old) participating in the Nurses' Health Study II cohort free of cancer, cardiovascular disease, diabetes, and asthma with no prior history of pneumonia.Measurements and Results: At baseline, participants reported their average sleep duration and whether this quantity was adequate for them. Questionnaires ascertaining a new pneumonia diagnosis were mailed every 2 years. Cases required physician diagnosis and chest radiograph confirmation. Cox proportional hazards models were used to assess the relative risk for incident pneumonia over 4 years. Over 217,500 person-years, 977 cases of pneumonia were identified. Relative to 8-h sleepers, both short and long sleep durations were associated with elevated pneumonia risk. The age-adjusted relative risk for pneumonia was 1.70 (95% CI 1.30-2.23) in those sleeping = 9 h. After adjusting for potential confounders, the relative risks were 1.39 (95% CI: 1.06-1.82) in those sleeping = 9 h. Perceived inadequate sleep was also associated with pneumonia with a relative risk of 1.50 (95% CI 1.29-1.74) in multivariate models.Conclusions: Both reduced and prolonged habitual sleep durations are associated with increased risk of pneumonia. Further research is needed to understand how sleep habits can influence immunity.