The Pocket Smell Test: Successfully discriminating probable Alzheimer's dementia from vascular dementia and major depression
The Pocket Smell Test: Successfully discriminating probable Alzheimer's dementia from vascular dementia and major depression
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DOI：
10.1176/appi.neuropsych.14.2.197
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发表时间：
2002-03-01
影响因子：
2.9
通讯作者：
Solomon, GS
中科院分区：
文献类型：
--
作者：
Duff, K;McCaffrey, RJ;Solomon, GS
本研究扩展了以前的嗅觉功能障碍（气味识别缺陷）的工作，通过使用袖珍嗅觉测试（PST）来区分阿尔茨海默病（AD），血管性痴呆（VaD）和抑郁症（MD）患者组。60例符合DSM-IV标准的AD、VaD或MD患者（每组20例）接受了PST评估，PST是气味识别的三项筛选措施，以及简易精神状态检查（MMSE）。即使在控制MMSE评分后，AD患者的PST评分也显著低于VaD或MD患者。PST评分大于或等于1（即，1或0正确）区分患有和不患有AD的患者，分类准确性为95%（灵敏度100%，特异性92.5%）。在老年患者中，嗅觉评估可能在AD与VaD与MD的鉴别诊断中具有诊断实用性。
The present study extended previous work on olfactory dysfunction (odor identification deficits) by using the Pocket Smell Test (PST) to discriminate between groups of patients with Alzheimer's disease (AD), vascular dementia (VaD), and major depression (MD). Sixty patients meeting, the DSM-IV criteria for either AD, VaD, or MD (20 per group) underwent assessment with the PST, a three-item screening measure of odor identification, and the Mini-Mental State Examination (MMSE). Patients with AD scored significantly lower than patients with either VaD or MD on the PST, even after controlling for MMSE scores. A PST score of greater than or equal to1 (i.e., 1 or 0 correct) discriminated between patients with and without AD with a classification accuracy of 95% (sensitivity 100%, specificity 92.5%). Olfactory assessment may be of diagnostic utility hi the differential diagnosis of AD versus VaD versus MD in elderly patients.