Sustainable catalysis : challenges and practices for the pharmaceutical and fine chemical industries
Sustainable catalysis : challenges and practices for the pharmaceutical and fine chemical industries
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发表时间：
2013
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通讯作者：
Peter J. Dunn;K. K. Hii-K.;M. Krische;Michael T. Williams
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作者：
Peter J. Dunn;K. K. Hii-K.;M. Krische;Michael T. Williams
前言vii前言ix贡献者xi缩写xiii 1避免LiAlH 4或B2 H6的酰胺的催化还原1 Deborah L. Dodds和大卫J. Cole-Hamilton 2酯的加氢37莱昂内尔A. Saudan 3使用转氨酶合成手性胺63 Nicholas J. Turner和Matthew D. Truppo 4西格列汀转氨酶的开发75 Jacob M.避免差原子经济性的直接酰胺形成试剂89本杰明M. Monks和Andrew Whiting 6硼酸和硼酸催化的直接酰胺化反应的工业应用111 Joanne E.放大图片作者：安德森，Jannine Cobb，Roman Davis，Peter J. Dunn，Russ N. Fitzgerald，and Alan J. Pettman 7 OH Activation for Nucleophilic Substitution 121 Jonathan M. J.威廉姆斯8应用氧化还原中性醇胺化在千克级合成GlyT 1抑制剂139 Martin A. Berliner 9烯烃复分解：从学术概念到商业催化剂163 Justyna Czaban，Christian Torborg，and Karol Grela 10大规模复分解反应的挑战和机遇：Ciluprevir的合成（BILN 2061）215 Nathan Yee，Xudong Wei，和Chris Senanayake 11杂环化合物的C H活化233 Koji Hirano和Masahiro Miura 12新Pd/Cu催化体系用于C H芳基化及其在制药过程中的应用269 Jinkun Huang，Xiang Wang，and Johann Chan 13 Diarylprolinol Silyl Ethers：Development and Application as Organic Catalysts 287 Hiroaki Gotoh and Yujiro Hayashi 14 Organocatalysis for Asymmetric Synthesis：从实验室到工厂317冯旭15氧化膦介导的有机转化的催化变体339 Stephen P. Marsden 16通过催化氢化和转移氢化形成C C键363 Joseph Moran和Michael J. Krische指数409
Foreword vii Preface ix Contributors xi Abbreviations xiii 1 Catalytic Reduction of Amides Avoiding LiAlH4 or B2H6 1 Deborah L. Dodds and David J. Cole-Hamilton 2 Hydrogenation of Esters 37 Lionel A. Saudan 3 Synthesis of Chiral Amines Using Transaminases 63 Nicholas J. Turner and Matthew D. Truppo 4 Development of a Sitagliptin Transaminase 75 Jacob M. Janey 5 Direct Amide Formation Avoiding Poor Atom Economy Reagents 89 Benjamin M. Monks and Andrew Whiting 6 Industrial Applications of Boric Acid and Boronic Acid-Catalyzed Direct Amidation Reactions 111 Joanne E. Anderson, Jannine Cobb, Roman Davis, Peter J. Dunn, Russ N. Fitzgerald, and Alan J. Pettman 7 OH Activation for Nucleophilic Substitution 121 Jonathan M.J. Williams 8 Application of a Redox-Neutral Alcohol Amination in the Kilogram-Scale Synthesis of a GlyT1 Inhibitor 139 Martin A. Berliner 9 Olefin Metathesis: From Academic Concepts to Commercial Catalysts 163 Justyna Czaban, Christian Torborg, and Karol Grela 10 Challenge and Opportunity in Scaling-up Metathesis Reaction: Synthesis of Ciluprevir (BILN 2061) 215 Nathan Yee, Xudong Wei, and Chris Senanayake 11 C H Activation of Heteroaromatics 233 Koji Hirano and Masahiro Miura 12 The Discovery of a New Pd/Cu Catalytic System for C H Arylation and Its Applications in a Pharmaceutical Process 269 Jinkun Huang, Xiang Wang, and Johann Chan 13 Diarylprolinol Silyl Ethers: Development and Application as Organocatalysts 287 Hiroaki Gotoh and Yujiro Hayashi 14 Organocatalysis for Asymmetric Synthesis: From Lab to Factory 317 Feng Xu 15 Catalytic Variants of Phosphine Oxide-Mediated Organic Transformations 339 Stephen P. Marsden 16 Formation of C C Bonds Via Catalytic Hydrogenation and Transfer Hydrogenation 363 Joseph Moran and Michael J. Krische Index 409