Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers
Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers
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DOI：
10.1207/s15327914nc432_5
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发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Folsom, AR
中科院分区：
文献类型：
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作者：
Harnack, L;Jacobs, DR;Folsom, AR
据推测，缺乏叶酸、蛋氨酸、维生素B-6和B-12的饮食会导致DNA低甲基化，从而增加患结肠直肠癌的风险。此外，有人提出，甲基拮抗剂酒精会增加叶酸摄入量低的人患结直肠癌的风险。来自爱荷华州妇女健康研究（一项基于人群的癌症发病率队列研究）的数据被用于检查叶酸、蛋氨酸、维生素B-6和B-12与13年随访期间结肠癌（n = 598）和直肠癌（n = 123）发生的关系。从食物频率调查问卷中没有发现叶酸、蛋氨酸、维生素B-6和维生素B-12与结肠癌发病率之间的独立关联。不同叶酸、维生素B-12和蛋氨酸摄入量的直肠癌校正相对危险度（RRs）相似，但随着维生素B-6摄入量的增加，RRs逐渐增加[P (for trend) = 0.03]。相对危险度（RRs）表明：1)高叶酸和高维生素B-12摄取量（RR = 0.59, 95%可信区间(CI) = 0.39-0.89）和2)高叶酸和高维生素B-6摄取量（RR = 0.65, 95% CI = 0.50-0.84）的人群中，近端结肠癌的发病率低于这些营养素摄取量最低的人群。高叶酸摄入量和低酒精摄入量的人群中，近端结肠癌的发病率也有所降低（RR = 0.44, 95% CI = 0.22-0.89）。研究结果对涉及DNA甲基化的饮食因素与结肠癌和直肠癌风险之间的关联提供了有限的支持。
It is hypothesized that diets deficient in folate, methionine, and vitamins B-6 and B-12 cause DNA hypomethylation and, as a result, increase risk of colorectal cancers. Furthermore, it is proposed that alcohol, a methyl group antagonist, increases risk of colorectal cancers among those with low intake of folate. Data from the Iowa Women's Health Study, a population-based cohort of incident cancer, were used to examine the relationship of folate, methionine, and vitamins B-6 and B-12 to occurrence of cancers of the colon (n = 598) and rectum (n = 123) over 13 yr of follow-up. There were no independent associations of folate, methionine, or vitamins B-6 and B-12 derived from a food frequency questionnaire with incidence of colon cancer. Adjusted relative risks (RRs) of rectal cancer were similar across categories of folate, vitamin B-12, and methionine intake, but RRs increased progressively with increasing intake of vitamin B-6 [P (for trend) = 0.03]. RRs suggested that incidence of cancer of the proximal colon was lower among those with 1) high folate and high vitamin B-12 intake [RR = 0.59, 95% confidence interval (CI) = 0.39-0.89] and 2) high folate and high vitamin B-6 intake (RR = 0.65, 95% CI = 0.50-0.84) than among those with the lowest intake of these nutrients. Incidence of cancer of the proximal colon was also somewhat lower among those with high folate and low alcohol intake (RR = 0.44, 95% CI = 0.22-0.89). Findings provide limited support for an association between dietary factors involved in DNA methylation and risk of cancers of the colon and rectum.