Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative.
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative.
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全球双极队列合作组织来自二极异性疾病的功能障碍的预测因素：来自七个国家的13个队列的结果。
作者：
持续性功能障碍在双相情感障碍（BD）中很常见，并受到许多人口统计学、临床和认知特征的影响。本项目的目的是估计和比较关键因素对社区功能的影响，在多个队列的良好表征的样本与BD的个人。来自7个国家的13个队列包括多个研究中心的n= 5，882例BD患者。统计方法包括系统统一应用各研究中心的分析。每个研究中心都进行了逻辑回归分析，以经验得出的“较高与较低功能”作为因变量，并选择临床和人口统计学变量作为预测因素。我们发现功能障碍的发生率很高，从41- 75%不等。在分析中包括该变量的12个队列中，有10个队列的社区功能低下与抑郁症状相关。较低的教育水平，更多的先前情绪发作，存在共病的物质使用障碍，以及更多的精神药物总量也与低功能相关。双相临床研究界准备共同努力，以表征损害的多维度贡献者，并解决阻碍患者完全康复的障碍。我们还必须确定使许多人能够在BD中茁壮成长并成功生活的核心特征。一项大规模的、全球性的、前瞻性的纵向研究，重点关注BD及其异质性表现，将作为一个发现平台，并促进重大进展，以优化每一个患有这种疾病的人的结局。
Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. Thirteen cohorts from 7 countries included n=5,882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived “higher versus lower function” as the dependent variable and selected clinical and demographic variables as predictors. We found high rates of functional impairment, ranging from 41–75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients’ complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
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影响因子：
6.9
作者：
Burdick KE;Russo M;Frangou S;Mahon K;Braga RJ;Shanahan M;Malhotra AK
通讯作者：
Malhotra AK
影响因子：
6.6
作者：
Jaeger, J;Berns, SM;Czobor, P
通讯作者：
Czobor, P
影响因子：
17.7
作者：
Altshuler, Lori L.;Kupka, Ralph W.;Zermeno, Melanie
通讯作者：
Zermeno, Melanie
影响因子：
5.4
作者：
Henry, Chantal;Godin, Ophelia;Etain, Bruno
通讯作者：
Etain, Bruno
影响因子：
3.3
作者：
Carney, Caroline P.;Jones, Laura E.
通讯作者：
Jones, Laura E.