Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy
Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy
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DOI：
10.1002/bjs.4053
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发表时间：
2003-04-01
影响因子：
9.6
通讯作者：
Maddern, GJ
中科院分区：
文献类型：
--
作者：
Court, FG;Wemyss-Holden, SA;Maddern, GJ
背景资料：对猪肝解剖结构的深入了解使其能够对节段性肝切除和肝再生以及肝移植技术进行潜在的研究。然而，节段性解剖在很大程度上仍然未知。本研究的目的是描绘节段性解剖学的猪肝与人类的比较。离体猪肝脏的注射铸造，可以直接观察动脉、静脉和胆汁供应。这是相关的使用多层面计算机断层扫描（CT）和三维reconstruction.Results：虽然猪肝脏的外部形态与人类的不同，节段解剖是非常相似的，在其血管和胆道tree.Conclusion：丙烯酸铸造的猪肝准确地描绘血管和胆道解剖，是一个有用的工具，进行实验性肝脏外科手术。猪和人类节段解剖结构之间的相似性允许家猪用作可比模型。三维CT重建还可以准确地可视化解剖结构，并可用于执行虚拟手术或评估节段体积。
Background: In-depth knowledge of pig liver anatomy allows potential research into segmental liver resections and hepatic regeneration, as well as liver transplantation techniques. The segmental anatomy, however, remains largely unknown. This study aimed to delineate the segmental anatomy of the porcine liver in comparison with that of the human.Methods: The segmental anatomy of the porcine liver was determined using acrylic! injection casting of ex vivo pig livers, allowing the arterial, venous and biliary supply to be visualized directly. This was correlated using multi-slice computed tomography (CT) and three-dimensional reconstructions.Results: Although the external morphology of the porcine liver differs from that of the human, the segmental anatomy is remarkably similar in term of its vascularity and biliary tree.Conclusion: Acrylic casting of the porcine liver accurately delineates the vascular and biliary anatomy, and is a useful tool for performing experimental liver surgery. The similarities between porcine and human segmental anatomy allow domestic swine to be used as a comparable model. Three-dimensional CT reconstructions can also accurately visualize the anatomy and may be used to perform virtual surgery, or to assess segmental volumes.