The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
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CD4/CD8 谱系：T 淋巴细胞的中央决策和外周修饰。
DOI：
10.1007/82_2013_323
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Ichiro Taniuchi,
中科院分区：
文献类型：
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作者：
Hirokazu Tanaka;Ichiro Taniuchi,
CD 4+辅助性T细胞和CD 8+细胞毒性T细胞是表达αβTCR的淋巴细胞的两个主要亚群，由常见的前体CD 4 + CD 8+双阳性（DP）胸腺细胞分化而来。胸腺中CD 4 +/CD 8+谱系的分叉是一个多层次的过程，并被认为最终导致这些功能亚群之间发育可塑性的丧失。在过去的十年中的进展加深了我们的理解的转录控制机制的CD 4与CD 8谱系的承诺。两种转录因子ThPOK和Runx 3之间的相互表达和拮抗性相互作用对于驱动胸腺细胞在这两种细胞命运之间做出决定至关重要。在这里，我们首先集中在调节ThPOK的表达及其在指导辅助性T细胞发育中的作用。然后，我们讨论了一个新的方面的ThPOK/Runx 3轴在修改CD 4 +T细胞功能暴露于肠道微环境。
CD4+helper and CD8+cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4+CD8+double-positive (DP) thymocytes. Bifurcation of the CD4+/CD8+lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental plasticity between these functional subsets. Advances in the last decade have deepened our understanding of the transcription control mechanisms governing CD4 versus CD8 lineage commitment. Reciprocal expression and antagonistic interplay between two transcription factors, ThPOK and Runx3, is crucial for driving thymocyte decisions between these two cell fates. Here, we first focus on the regulation of ThPOK expression and its role in directing helper T cell development. We then discuss a novel aspect of the ThPOK/Runx3 axis in modifying CD4+T cell function upon exposure to gut microenvironment.