Regulation of promyogenic signal transduction by cell-cell contact and adhesion.
Regulation of promyogenic signal transduction by cell-cell contact and adhesion.
复制标题
DOI：
10.1016/j.yexcr.2010.05.008
复制
发表时间：
2010-11-01
影响因子：
3.7
通讯作者：
Krauss RS
中科院分区：
文献类型：
--
作者：
Krauss RS
骨骼肌成肌细胞分化涉及肌肉特异性转录程序的获得和形态变化，包括融合成多核肌纤维。分化受到细胞外信号传导的调节，包括细胞间接触和粘附。钙粘蛋白和 Ig 粘附受体与肌生成的不同但重叠的阶段有关。 N-钙粘蛋白通过 Ig 受体 Cdo 发出信号来激活 p38 MAP 激酶，而 Ig 受体 neogenin 发出信号来激活 FAK；这两个过程都促进肌肉特异性基因表达和成肌细胞融合。 M-钙粘蛋白激活 Rac1 以增强融合。特定的 Ig 受体（Kirre、Sns）对于果蝇中的成肌细胞融合至关重要，也通过 Rac 发出信号，而 Kirre 和 Sns 的脊椎动物直系同源物具有部分保守的功能。缺乏由多种受体（例如 Rac1）激活的特定细胞质信号因子的小鼠在体内具有很强的肌肉表型。相比之下，缺乏位于这些因子上游的个体粘附受体的小鼠具有适度的表型。受体之间的冗余可能是造成这种情况的原因。许多哺乳动物 Ig 受体和钙粘蛋白彼此结合，这些复合物内的多价相互作用可能需要去除多种成分才能揭示体内的显着缺陷。然而，体内的小鼠粘附受体限速可能尚未被识别或充分评估。
Skeletal myoblast differentiation involves acquisition of the muscle-specific transcriptional program and morphological changes, including fusion into multinucleated myofibers. Differentiation is regulated by extracellular signaling cues, including cell-cell contact and adhesion. Cadherin and Ig adhesion receptors have been implicated in distinct but overlapping stages of myogenesis. N-cadherin signals through the Ig receptor Cdo to activate p38 MAP kinase, while the Ig receptor neogenin signals to activate FAK; both processes promote muscle-specific gene expression and myoblast fusion. M-cadherin activates Rac1 to enhance fusion. Specific Ig receptors (Kirre, Sns) are essential for myoblast fusion in Drosophila, also signaling through Rac, and vertebrate orthologs of Kirre and Sns have partially conserved function. Mice lacking specific cytoplasmic signaling factors activated by multiple receptors (e.g., Rac1) have strong muscle phenotypes in vivo. In contrast, mice lacking individual adhesion receptors that lie upstream of these factors have modest phenotypes. Redundancy among receptors may account for this. Many of the mammalian Ig receptors and cadherins associate with each other, and multivalent interactions within these complexes may require removal of multiple components to reveal dramatic defects in vivo. Nevertheless, it is possible that the murine adhesion receptors rate-limiting in vivo have not yet been identified or fully assessed.
登录
查看更多内容
影响因子：
3.3
作者：
Bae, Gyu-Un;Yang, Youn-Joo;Krauss, Robert S.
通讯作者：
Krauss, Robert S.
影响因子：
5.3
作者：
Donoviel, DB;Freed, DD;Powell, DR
通讯作者：
Powell, DR
影响因子：
7.8
作者：
Charlton, CA;Mohler, WA;Blau, HM
通讯作者：
Blau, HM
影响因子：
3.7
作者：
Capkovic, Katie L.;Stevenson, Severin;Cornelison, D. D. W.
通讯作者：
Cornelison, D. D. W.
影响因子：
11.8
作者：
Cole, F;Zhang, W;Krauss, RS
通讯作者：
Krauss, RS