In vitro antimalarial activity of biflavonoids from Wikstroemia indica
In vitro antimalarial activity of biflavonoids from Wikstroemia indica
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DOI：
10.1055/s-2004-815462
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发表时间：
2004-01-01
期刊：
影响因子：
2.7
通讯作者：
Omura, S
中科院分区：
文献类型：
--
作者：
Nunome, S;Ishiyama, A;Omura, S
在我们对药用草药提取物的体外抗疟筛选的研究中，Wikstroemia indica 根的正丁醇提取物显示出有效的抑制作用。对活性提取物进行分级分离，分离出两种双黄酮类化合物：sikokianin B (1) 和 sikokianin C (2)，对恶性疟原虫的氯喹耐药菌株的 IC50 值分别为 0.54 mug/mL 和 0.56 mug/mL。这是1和2生物活性的首次报道。由于I的结构尚未确定，我们通过H-1-和C-13-NMR确认了其构象。
in our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B (1) and sikokianin C (2) with IC50 values 0.54 mug/mL and 0.56 mug/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of I has remained unsettled, we confirmed the conformation by H-1- and C-13-NMR.