Obesity Increases and Physical Activity Decreases Lower Urinary Tract Symptom Risk in Older Men: The Osteoporotic Fractures in Men Study
Obesity Increases and Physical Activity Decreases Lower Urinary Tract Symptom Risk in Older Men: The Osteoporotic Fractures in Men Study
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DOI：
10.1016/j.eururo.2011.07.040
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发表时间：
2011-12-01
期刊：
影响因子：
23.4
通讯作者：
Marshall, Lynn M.
中科院分区：
文献类型：
--
作者：
Parsons, J. Kellogg;Messer, Karen;Marshall, Lynn M.
背景资料：预防老年人慢性下尿路症状（LUTS）的两个潜在目标是肥胖和体力活动。Objective：To examine associations of adiposity and physical activity with incident LUTS in community-dwelling elderly men.Design，setting，and participants：The Osteoporotic Fractures in Men Study（MrOS）是一项前瞻性队列研究，对象为年龄≥ 65岁的男性。无LUTS和基线LUTS治疗史的MrOS参与者纳入本分析。测量：肥胖用体重指数（BMI）测量，体力活动用老年人体力活动量表（PASE）和每日步行自我报告测量，LUTS用美国泌尿协会症状指数测量。基线时1695名参与者的平均年龄（标准差[SD]）为72（5）岁。在平均（SD）4.6（0.5）年的随访中，524（31%）例男性报告了LUTS事件。在多变量分析中，与基线体重正常的男性（BMI = 30 kg/m2）相比，男性发生LUTS的可能性分别高出29%（校正比值比[ORadj]：1.29; 95%置信区间[CI]，1.00-1.68）和41%（ORadj：1.41; 95% CI，1.03-1.93）。身体活动最高四分位数的男性为29%（ORadj：0.71; 95%CI，0.53-0.97），每天步行的男性比久坐的同龄人发生LUTS的可能性低20%（ORadj：0.80; 95%CI，0.65-0.98），调整BMI。MrOS的均匀组成可能会降低这些结果的外部有效性。结论：在老年男性中，肥胖和较高的体力活动分别与LUTS事件风险的增加和降低相关。预防慢性泌尿系统症状是老年男性运动的另一个潜在健康益处。(C)2011年欧洲泌尿外科协会。由Elsevier B出版。V.保留所有权利。
Background: Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity.Objective: To examine associations of adiposity and physical activity with incident LUTS in community-dwelling older men.Design, setting, and participants: The Osteoporotic Fractures in Men Study (MrOS) is a prospective cohort of men >= 65 yr of age. MrOS participants without LUTS and a history of LUTS treatment at baseline were included in this analysis.Measurements: Adiposity was measured with body mass index (BMI), physical activity with the Physical Activity Scale for the Elderly (PASE) and self-report of daily walking, and LUTS with the American Urological Association Symptom Index.Results and limitations: The mean age (standard deviation [SD]) of the 1695 participants was 72 (5) yr at baseline. At a mean (SD) follow-up of 4.6 (0.5) yr, 524 (31%) of men reported incident LUTS. In multivariate analyses, compared with men of normal weight at baseline (BMI = 30 kg/m(2)) men were 29% (adjusted odds ratio [ORadj]: 1.29; 95% confidence interval [CI], 1.00-1.68) and 41% (ORadj: 1.41; 95% CI, 1.03-1.93) more likely to develop LUTS, respectively. Men in the highest quartile of physical activity were 29% (ORadj: 0.71; 95% CI, 0.53-0.97) and those who walked daily 20% (ORadj: 0.80; 95% CI, 0.65-0.98) less likely than their sedentary peers to develop LUTS, adjusting for BMI. The homogeneous composition of MrOS potentially diminishes the external validity of these results.Conclusions: In older men, obesity and higher physical activity are associated with increased and decreased risks of incident LUTS, respectively. Prevention of chronic urinary symptoms represents another potential health benefit of exercise in elderly men. (C) 2011 European Association of Urology. Published by Elsevier B. V. All rights reserved.